PF-3450074

Base Information

• Chemical Name: PF-3450074
• CAS No.: 1352879-65-2
• Molecular Formula: C₂₇H₂₇N₃O₂
• Molecular Weight: 425.53
• Mol file: 1352879-65-2.mol

Synonyms:(S)-N-methyl-2-(2-(2-methyl-1H-indol-3-yl)-acetamido)-N,3-diphenylpropanamide

Chemical Property of PF-3450074

Chemical Property:

• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble5mg/mL, clear (warmed)

Purity/Quality:

97% ^*data from raw suppliers

PF74 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PF-3450074

There total 6 articles about PF-3450074 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(2-(2-methyl-1H-indol-3-yl)acetyl)-D-phenylalanine + N-methylaniline (100-61-8) → (S)-N-methyl-2-(2-(2-methyl-1H-indol-3-yl)-acetamido)-N,3-diphenylpropanamide (1352879-65-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 48h; Heating;

DOI:10.3390/molecules26133919

Reference yield:

2-methyl-3-indoleacetic acid (1912-43-2) → (S)-N-methyl-2-(2-(2-methyl-1H-indol-3-yl)-acetamido)-N,3-diphenylpropanamide (1352879-65-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

2: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 70 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1128/AAC.00646-15

Reference yield:

methyl (2-(2-methyl-1H-indol-3-yl)acetyl)-L-phenylalaninate → (S)-N-methyl-2-(2-(2-methyl-1H-indol-3-yl)-acetamido)-N,3-diphenylpropanamide (1352879-65-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 70 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1128/AAC.00646-15

upstream raw materials:

2-methyl-3-indoleacetic acid

methyl (2S)-2-amino-3-phenylpropanoate

N-methylaniline