2-((((Z)-2-(((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)-amino)oxy)-2-methylpropanoic acid tert-butyl ester

Base Information

Chemical Name:2-((((Z)-2-(((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)-amino)oxy)-2-methylpropanoic acid tert-butyl ester
CAS No.:1380110-32-6
Molecular Formula:C₄₃H₅₂N₈O₁₁S
Molecular Weight:888.999
Hs Code.:

2-((((Z)-2-(((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)-amino)oxy)-2-methylpropanoic acid tert-butyl ester

Synonyms:2-((((Z)-2-(((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)-amino)oxy)-2-methylpropanoic acid tert-butyl ester

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Chemical Property of 2-((((Z)-2-(((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)-amino)oxy)-2-methylpropanoic acid tert-butyl ester

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Technology Process of 2-((((Z)-2-(((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)-amino)oxy)-2-methylpropanoic acid tert-butyl ester

There total 21 articles about 2-((((Z)-2-(((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)-amino)oxy)-2-methylpropanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1380109-80-7
2-(aminomethyl)-1,5-bis(benzyloxy)-1,4-dihydropyridin-4-one

: 1380109-70-5
tert-butyl 2-(((Z)-(2-(((2R,3S)-2-(aminomethyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)amino)oxy)-2-methylpropanoate

: 530-62-1
1,1'-carbonyldiimidazole

: 1380110-32-6
2-((((Z)-2-(((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)-amino)oxy)-2-methylpropanoic acid tert-butyl ester

Guidance literature:: 2-(aminomethyl)-1,5-bis(benzyloxy)-1,4-dihydropyridin-4-one; 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 0.0833333h;

tert-butyl 2-(((Z)-(2-(((2R,3S)-2-(aminomethyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)amino)oxy)-2-methylpropanoate; In tetrahydrofuran; at 20 - 25 ℃; for 15h;

Reference yield: 58.0%

: 1229937-12-5
(Z)-2-(((1-(2-((tert-butoxycarbonyl)-amino)thiazol-4-yl)-2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid tert-butyl ester

: 1380110-42-8
1-(((2R,3S)-3-amino-4-oxoazetidin-2-yl)-methyl)-3-((1,5-bis(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)urea trifluoroacetic acid salt

: 1380110-32-6
2-((((Z)-2-(((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)-amino)oxy)-2-methylpropanoic acid tert-butyl ester

Guidance literature:: With dmap; In acetonitrile; at 40 ℃; for 16h; Molecular sieve 4AE;

Reference yield:

: 137088-65-4
(Z)-2-([[1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl]oxy]imino)-2-(2-[[(tert-butoxy)carbonyl]amino]-1,3-thiazol-4-yl)acetic acid

: 1380110-32-6
2-((((Z)-2-(((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-oxoethylidene)-amino)oxy)-2-methylpropanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide / dichloromethane / 3.5 h / 0 - 25 °C

2: dmap / acetonitrile / 16 h / 40 °C / Molecular sieve 4AE

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;