1-(((2R,3S)-3-amino-4-oxoazetidin-2-yl)-methyl)-3-((1,5-bis(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)urea trifluoroacetic acid salt

Base Information

Chemical Name:1-(((2R,3S)-3-amino-4-oxoazetidin-2-yl)-methyl)-3-((1,5-bis(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)urea trifluoroacetic acid salt
CAS No.:1380110-42-8
Molecular Formula:C₂HF₃O₂*C₂₅H₂₇N₅O₅
Molecular Weight:591.544
Hs Code.:

Synonyms:1-(((2R,3S)-3-amino-4-oxoazetidin-2-yl)-methyl)-3-((1,5-bis(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)urea trifluoroacetic acid salt

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Chemical Property of 1-(((2R,3S)-3-amino-4-oxoazetidin-2-yl)-methyl)-3-((1,5-bis(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)urea trifluoroacetic acid salt

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Technology Process of 1-(((2R,3S)-3-amino-4-oxoazetidin-2-yl)-methyl)-3-((1,5-bis(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)urea trifluoroacetic acid salt

There total 15 articles about 1-(((2R,3S)-3-amino-4-oxoazetidin-2-yl)-methyl)-3-((1,5-bis(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)urea trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380112-29-7
CH₄O₃S*C₂₀H₂₀N₂O₃

: 1380110-42-8
1-(((2R,3S)-3-amino-4-oxoazetidin-2-yl)-methyl)-3-((1,5-bis(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)urea trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / dichloromethane; water / 1 h / 22 °C

2: potassium phosphate; dipotassium peroxodisulfate / acetonitrile; water / 1.5 h / 75 °C

3: trifluoroacetic acid / 3 h / 0 °C

With potassium phosphate; dipotassium peroxodisulfate; trifluoroacetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1021/jm400560z

Reference yield:

: 1380110-39-3
tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-1-(2,4-dimethoxybenzyl)-4-oxoazetidin-3-yl)-carbamate

: 1380110-42-8
1-(((2R,3S)-3-amino-4-oxoazetidin-2-yl)-methyl)-3-((1,5-bis(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)urea trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1: dipotassium hydrogenphosphate; dipotassium peroxodisulfate / water; acetonitrile / 1.5 h / 75 °C / pH 6 - 6.5

2: trifluoroacetic acid / methoxybenzene / 3 h / -5 °C / Inert atmosphere

With dipotassium hydrogenphosphate; dipotassium peroxodisulfate; trifluoroacetic acid; In water; methoxybenzene; acetonitrile;

Reference yield:

: 1380110-40-6
tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)carbamate

: 76-05-1
trifluoroacetic acid

: 1380110-42-8
1-(((2R,3S)-3-amino-4-oxoazetidin-2-yl)-methyl)-3-((1,5-bis(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)urea trifluoroacetic acid salt

: C₂₆H₂₇N₅O₇*C₂HF₃O₂

Guidance literature:: tert-butyl ((2R,3S)-2-((3-((1,5-bis-(benzyloxy)-4-oxo-1,4-dihydropyridin-2-yl)methyl)ureido)-methyl)-4-oxoazetidin-3-yl)carbamate; trifluoroacetic acid; With methoxybenzene; at -10 - -5 ℃; for 3h; Inert atmosphere;

In tert-butyl methyl ether; at 10 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.oprd.9b00374