2-<(o,o'-dimethyl)-2'-acetanilidyl>-9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one

Base Information

• Chemical Name: 2-<(o,o'-dimethyl)-2'-acetanilidyl>-9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one
• CAS No.: 113400-82-1
• Molecular Formula: C₂₂H₂₄N₄O₂
• Molecular Weight: 376.458

Synonyms:2-<(o,o'-dimethyl)-2'-acetanilidyl>-9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one

Chemical Property of 2-<(o,o'-dimethyl)-2'-acetanilidyl>-9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one

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Technology Process of 2-<(o,o'-dimethyl)-2'-acetanilidyl>-9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one

There total 3 articles about 2-<(o,o'-dimethyl)-2'-acetanilidyl>-9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-bromo-N-(2,6-dimethyl-phenyl)-acetamide (32433-61-7) + 9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one (112779-39-2) → 2-<(o,o'-dimethyl)-2'-acetanilidyl>-9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one (113400-82-1)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Heating;

DOI:10.1002/jhet.5570240550

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 2-<(o,o'-dimethyl)-2'-acetanilidyl>-9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one (113400-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / polyphosphoric acid / 6 h / oil-bath 120 deg C

2: 75 percent / potassium carbonate / acetone / 5 h / Heating

With PPA; potassium carbonate; In acetone;

DOI:10.1002/jhet.5570240550

Reference yield:

3-methoxycarbonyl-4-piperidone hydrochloride (1414958-07-8) → 2-<(o,o'-dimethyl)-2'-acetanilidyl>-9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one (113400-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / polyphosphoric acid / 6 h / oil-bath 120 deg C

2: 75 percent / potassium carbonate / acetone / 5 h / Heating

With PPA; potassium carbonate; In acetone;

DOI:10.1002/jhet.5570240550

upstream raw materials:

2-bromo-N-(2,6-dimethyl-phenyl)-acetamide

9-methyl-1,2,3,4-tetrahydro-11H-dipyrido<1,2-a:4,3-d>pyrimidin-11-one

2-Amino-6-methylpyridine

3-methoxycarbonyl-4-piperidone hydrochloride

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