5-PYRID-4-YLTHIOPHENE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-PYRID-4-YLTHIOPHENE-2-CARBOXYLIC ACID
• CAS No.: 216867-32-2
• Molecular Formula: C10H7 N O2 S
• Molecular Weight: 205.237
• Hs Code.: 2934999090
• Mol file: 216867-32-2.mol

Synonyms:5-(4-Pyridyl)thiophene-2-carboxylicacid; 5-(Pyridin-4-yl)thiophene-2-carboxylic acid

Chemical Property of 5-PYRID-4-YLTHIOPHENE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.643
• Boiling Point: 407.7°Cat760mmHg
• Flash Point: 200.4°C
• PSA: 78.43000
• Density: 1.368g/cm³
• LogP: 2.50830

Purity/Quality:

97% ^*data from raw suppliers

5-Pyrid-4-ylthiophene-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-PYRID-4-YLTHIOPHENE-2-CARBOXYLIC ACID

There total 6 articles about 5-PYRID-4-YLTHIOPHENE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-carboxythiophene-5-boronic acid + 4-bromopyridine hydrochloride (19524-06-2) → 5-(pyridin-4-yl)thiophene-2-carboxylic acid (216867-32-2)

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); ethanol; water; at 150 ℃; for 0.166667h;

Reference yield:

C12H11NO2S (866524-09-6) → 5-(pyridin-4-yl)thiophene-2-carboxylic acid (216867-32-2)

Guidance literature:

C₁₂H₁₁NO₂S; With sodium hydroxide; water; In ethanol; at 20 ℃; for 16h;

With hydrogenchloride; In water; pH=3 - 4;

Reference yield:

5-bromo-2-thiophenecarboxylic acid methyl ester (62224-19-5) + 4-pyridylboronic acid (1692-15-5) → 5-(pyridin-4-yl)thiophene-2-carboxylic acid (216867-32-2)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; for 72h; Heating / reflux;

upstream raw materials:

4-bromopyridin

4-bromopyridine hydrochloride

C₁₂H₁₁NO₂S

5-bromo-2-thiophenecarboxylic acid methyl ester

Downstream raw materials:

N-(3-methoxybenzyl)-5-(4-pyridinyl)-2-thiophenecarboxamide

N-(2-phenylethyl)-5-(4-pyridinyl)-2-thiophenecarboxamide

C₂₈H₂₄N₆O₃S