N,4-bis(3-(pyridin-3-ylmethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Base Information

Chemical Name:N,4-bis(3-(pyridin-3-ylmethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
CAS No.:1616474-36-2
Molecular Formula:C₃₀H₂₄N₆O₂
Molecular Weight:500.56
Hs Code.:

Synonyms:N,4-bis(3-(pyridin-3-ylmethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

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Chemical Property of N,4-bis(3-(pyridin-3-ylmethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

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Technology Process of N,4-bis(3-(pyridin-3-ylmethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

There total 11 articles about N,4-bis(3-(pyridin-3-ylmethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 105326-54-3
3-(pyridin-3-ylmethoxy)aniline

: 1616474-12-4
C₁₈H₁₃ClN₄O

: 1616474-36-2
N,4-bis(3-(pyridin-3-ylmethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos; In tert-butyl alcohol; for 16h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2014.05.033

Reference yield:

: 1250978-27-8
3-((3-iodophenoxy)methyl)pyridine

: 1616474-36-2
N,4-bis(3-(pyridin-3-ylmethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 1 h / Inert atmosphere; Reflux

3: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate / tert-butyl alcohol / 16 h / Inert atmosphere; Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; potassium carbonate; XPhos; In 1,4-dioxane; water; dimethyl sulfoxide; tert-butyl alcohol; 1: |Miyaura Borylation Reaction / 2: |Suzuki Coupling / 3: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.tet.2014.05.033

Reference yield:

: 39929-79-8
7-deazaxanthine

: 1616474-36-2
N,4-bis(3-(pyridin-3-ylmethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 18 h / 75 - 105 °C

2: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 1 h / Inert atmosphere; Reflux

4: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate / tert-butyl alcohol / 16 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; trichlorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 3: |Suzuki Coupling / 4: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.tet.2014.05.033