(6R,8R)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole

Base Information

• Chemical Name: (6R,8R)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole
• CAS No.: 152784-99-1
• Molecular Formula: C₂₆H₂₅NO₄S₂
• Molecular Weight: 479.621
• Mol file: 152784-99-1.mol

Synonyms:(6R,8R)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole

Chemical Property of (6R,8R)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R,8R)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole

There total 2 articles about (6R,8R)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

(3R,5S)-2-[3-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-2-hydroxy-propyl]-3,5-dimethyl-cyclopentanone (1025879-24-6) → (6R,8R)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole (152784-99-1) + (6R,8S)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole (152708-75-3)

Guidance literature:

With toluene-4-sulfonic acid; phenylmethanethiol;

DOI:10.1016/S0040-4039(00)74096-2

Reference yield:

(αξ)-α-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>methyl-1-(phenylsulfonyl)-α-<(phenylsulfonyl)methyl>-1H-pyrrole-3-methanol → (6R,8R)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole (152784-99-1) + (6R,8S)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole (152708-75-3)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; toluene-4-sulfonic acid; phenylmethanethiol; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, water, RT, 19 h, 2.) PhCl, reflux, 1.5 h;

DOI:10.1248/cpb.42.854

Reference yield: 91.0%

(6R,8R)-6,8-dimethyl-1-(phenylsulfonyl)-4-(phenylsulfonyl)methyl-1,6,7,8-tetrahydrocyclopentindole (152784-99-1) + allyl-trimethyl-silane (762-72-1) → (6R,8R)-4-(3-butenyl)-6,8-dimethyl-1-(phenylsulfonyl)-1,6,7,8-tetrahydrocyclopentindole (152784-93-5)

Guidance literature:

With ethylaluminum dichloride;

DOI:10.1016/S0040-4039(00)74096-2

upstream raw materials:

(3R,5S)-2-[3-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-2-hydroxy-propyl]-3,5-dimethyl-cyclopentanone

Downstream raw materials:

(6R,8R)-4-(3-butenyl)-6,8-dimethyl-1-(phenylsulfonyl)-1,6,7,8-tetrahydrocyclopentindole

(6R,8R)-4-<(E)-1-butenyl>-6,8-dimethyl-1-(phenylsulfonyl)-1,6,7,8-tetrahydrocyclopentindole