Technology Process of 1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-1-yl)ethan-1-one
There total 4 articles about 1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-1-yl)ethan-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
dichloro bis(acetonitrile) palladium(II);
In
1,4-dioxane;
at 110 ℃;
for 4h;
DOI:10.1021/jo800727s
- Guidance literature:
-
With
2,6-di-tert-butyl-4-methyl-phenol; potassium carbonate; 2-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; tris<3,5-bis(trifluoromethyl)phenyl>phosphane; palladium dichloride;
In
1,2-dichloro-ethane;
at 120 ℃;
for 12h;
Inert atmosphere;
Sealed tube;
DOI:10.1002/anie.202006740
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 0 °C / Inert atmosphere; Sealed tube
2: palladium dichloride; 2-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine; tris<3,5-bis(trifluoromethyl)phenyl>phosphane; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; potassium carbonate; 2,6-di-tert-butyl-4-methyl-phenol / 1,2-dichloro-ethane / 12 h / 120 °C / Inert atmosphere; Sealed tube
With
pyridine; 2,6-di-tert-butyl-4-methyl-phenol; potassium carbonate; 2-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; tris<3,5-bis(trifluoromethyl)phenyl>phosphane; palladium dichloride;
In
dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/anie.202006740
