14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one

Base Information

• Chemical Name: 14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
• CAS No.: 1316852-06-8
• Molecular Formula: C₂₄H₁₉N₃O
• Molecular Weight: 365.434

Synonyms:14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one

Chemical Property of 14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one

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Technology Process of 14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one

There total 11 articles about 14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2-(phenylamino)phenyl)(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)methanone → 14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one (1316852-06-8)

Guidance literature:

With (R)-1,1'-binaphthyl-2,2'-phosphoric acid; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In 1,4-dioxane; at 25 ℃; for 1h; Irradiation;

DOI:10.1002/anie.201906112

Reference yield: 92.0%

N-(2-(1H-indol-3-yl)ethyl)-2-(phenylamino)benzamide + orthoformic acid triethyl ester (122-51-0) → 14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one (1316852-06-8)

Guidance literature:

With boron trifluoride diethyl etherate; In N,N-dimethyl-formamide; at 100 ℃; for 5h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;

DOI:10.1039/c9cc00434c

Reference yield: 90.0%

→ 14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one (1316852-06-8)

Guidance literature:

With boron trifluoride diethyl ether complex; In N,N-dimethyl-formamide; for 6h; Inert atmosphere;

upstream raw materials:

3,4-dihydro-β-carboline

2-(phenylamino)benzoyl chloride

2-(phenylamino)benzoic acid

orthoformic acid triethyl ester

Downstream raw materials:

14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione

8-acetyloxy-14-phenyl-1,2-dihydroquinolino-[2',3':3,4]pyrrolo[2,1-b]quinazolin-5-one

8-chloro-14-phenyl-1,2-dihydroquinolino-[2',3':3,4]pyrrolo[2,1-b]quinazolin-5-one

8-morpholino-14-phenyl-1,2-dihydroquinol-ino[2',3':3,4]pyrrolo[2,1-b]quinazolin-5-one

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