14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione

Base Information

Chemical Name:14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione
CAS No.:1316852-08-0
Molecular Formula:C₂₄H₁₇N₃O₂
Molecular Weight:379.418
Hs Code.:

Synonyms:14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione

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Chemical Property of 14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione

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Technology Process of 14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione

There total 3 articles about 14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1316852-06-8
14-(3-(trifluoromethyl)phenyl)-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one

: 1316852-08-0
14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione

Guidance literature:: With potassium tert-butylate; oxygen; In N,N-dimethyl-formamide; at 20 ℃; for 7h;
DOI:10.1016/j.tet.2011.05.120

Reference yield:

: 91-40-7
2-(phenylamino)benzoic acid

: 1316852-08-0
14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / toluene / 0.5 h / 0 °C / Reflux

2: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

3: potassium tert-butylate; oxygen / N,N-dimethyl-formamide / 7 h / 20 °C

With thionyl chloride; potassium tert-butylate; oxygen; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; 3: Witkop-Winterfeldt oxidation;
DOI:10.1016/j.tet.2011.05.120

Reference yield:

: 57623-73-1
2-(phenylamino)benzoyl chloride

: 1316852-08-0
14-phenyl-1,2-dihydroquinolino[2',3':3,4]-pyrrolo[2,1-b]quinazoline-5,8(13H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

2: potassium tert-butylate; oxygen / N,N-dimethyl-formamide / 7 h / 20 °C

With potassium tert-butylate; oxygen; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 2: Witkop-Winterfeldt oxidation;
DOI:10.1016/j.tet.2011.05.120