1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea

Base Information

• Chemical Name: 1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea
• CAS No.: 1260228-58-7
• Molecular Formula: C₃₁H₂₇N₃O₃
• Molecular Weight: 489.574
• Mol file: 1260228-58-7.mol

Synonyms:1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea

Chemical Property of 1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea

There total 6 articles about 1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea → 1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea (1260228-58-7)

Guidance literature:

With tetrabutylammonium acetate; In 5,5-dimethyl-1,3-cyclohexadiene; at 80 ℃; for 3h;

DOI:10.1021/ol102659n

Reference yield:

benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate (1260228-55-4) → 1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea (1260228-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium / methanol

2: dichloromethane / Inert atmosphere

With hydrogen; palladium; In methanol; dichloromethane;

DOI:10.1021/ol102659n

Reference yield:

2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylbenzoic acid (297757-12-1,297757-33-6,297757-34-7) → 1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea (1260228-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.17 h / Inert atmosphere

1.2: 3 h / 20 - 85 °C / Inert atmosphere

2.1: hydrogen; palladium / methanol

3.1: dichloromethane / Inert atmosphere

With diphenyl phosphoryl azide; hydrogen; palladium; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/ol102659n

upstream raw materials:

benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate

1-(2-amino-6-methylphenyl)-3,3-diphenylpyrrolidine-2,5-dione

benzyl isothiocyanate

3-methylantranilic acid