benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate

Base Information

• Chemical Name: benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate
• CAS No.: 1260228-55-4
• Molecular Formula: C₃₁H₂₆N₂O₄
• Molecular Weight: 490.558
• Mol file: 1260228-55-4.mol

Synonyms:benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate

Chemical Property of benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate

There total 2 articles about benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylbenzoic acid (297757-12-1,297757-33-6,297757-34-7) + benzyl alcohol (100-51-6,185532-71-2) → benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate (1260228-55-4)

Guidance literature:

2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylbenzoic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; for 0.166667h; Inert atmosphere;

benzyl alcohol; In toluene; at 20 - 85 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol102659n

Reference yield:

3-methylantranilic acid (4389-45-1) → benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate (1260228-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 150 °C / neat (no solvent, solid phase)

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.17 h / Inert atmosphere

2.2: 3 h / 20 - 85 °C / Inert atmosphere

With diphenyl phosphoryl azide; triethylamine; In toluene;

DOI:10.1021/ol102659n

Reference yield:

benzyl (2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)carbamate (1260228-55-4) → 1-(2-amino-6-methylphenyl)-3,3-diphenylpyrrolidine-2,5-dione (1293370-17-8)

Guidance literature:

With hydrogen; palladium; In methanol;

DOI:10.1021/ol102659n

upstream raw materials:

3-methylantranilic acid

2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylbenzoic acid

benzyl alcohol

Downstream raw materials:

1-(2-amino-6-methylphenyl)-3,3-diphenylpyrrolidine-2,5-dione

1-benzyl-3-(2-(2,5-dioxo-3,3-diphenylpyrrolidin-1-yl)-3-methylphenyl)urea