tert-butyloxycarbonyl-4-(2-piperidyl)benzylamine

Base Information

• Chemical Name: tert-butyloxycarbonyl-4-(2-piperidyl)benzylamine
• CAS No.: 864934-27-0
• Molecular Formula: C₁₇H₂₆N₂O₂
• Molecular Weight: 290.406
• Mol file: 864934-27-0.mol

Synonyms:tert-butyloxycarbonyl-4-(2-piperidyl)benzylamine

Chemical Property of tert-butyloxycarbonyl-4-(2-piperidyl)benzylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of tert-butyloxycarbonyl-4-(2-piperidyl)benzylamine

There total 3 articles about tert-butyloxycarbonyl-4-(2-piperidyl)benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-(2-pyridyl)benzaldehyede oxime (864263-37-6) → tert-butyloxycarbonyl-4-(2-pyridyl)phenylmethylamine (864934-26-9) + tert-butyloxycarbonyl-4-(2-piperidyl)benzylamine (864934-27-0)

Guidance literature:

4-(2-pyridyl)benzaldehyede oxime; With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 18h; under 3800.26 Torr; Large scale reaction;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Large scale reaction;

DOI:10.1021/op800284k

Reference yield: 65.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-(2-pyridyl)benzaldehyede oxime (864263-37-6) → tert-butyloxycarbonyl-4-(2-piperidyl)benzylamine (864934-27-0)

Guidance literature:

4-(2-pyridyl)benzaldehyede oxime; With palladium 10% on activated carbon; hydrogen; acetic acid; In ethanol; at 20 ℃; for 18h; under 3800.26 Torr; Large scale reaction;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Large scale reaction;

DOI:10.1021/op800284k

Reference yield:

(4-pyridin-2-yl-benzyl)-carbamic acid tert-butyl ester; hydrochloride → tert-butyloxycarbonyl-4-(2-piperidyl)benzylamine (864934-27-0)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol; under 3102.89 Torr;

DOI:10.1016/j.bmcl.2005.05.133

upstream raw materials:

di-tert-butyl dicarbonate

4-(2-pyridyl)benzaldehyede oxime

Downstream raw materials:

2-(4-aminomethyl-phenyl)-piperidine-1-carboxylic acid methyl ester

2-{4-[(4-methyl-3-nitro-pyridin-2-ylamino)-methyl]-phenyl}-piperidine-1-carboxylic acid methyl ester