(S)-N-(1-hydroxy-3-phenylpropan-2-yl)-3,5-bis(trifluoromethyl)benzamide

Base Information

Chemical Name:(S)-N-(1-hydroxy-3-phenylpropan-2-yl)-3,5-bis(trifluoromethyl)benzamide
CAS No.:1443529-51-8
Molecular Formula:C₁₈H₁₅F₆NO₂
Molecular Weight:391.313
Hs Code.:

Synonyms:(S)-N-(1-hydroxy-3-phenylpropan-2-yl)-3,5-bis(trifluoromethyl)benzamide

Suppliers and Price of (S)-N-(1-hydroxy-3-phenylpropan-2-yl)-3,5-bis(trifluoromethyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(1-hydroxy-3-phenylpropan-2-yl)-3,5-bis(trifluoromethyl)benzamide

Chemical Property:

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Technology Process of (S)-N-(1-hydroxy-3-phenylpropan-2-yl)-3,5-bis(trifluoromethyl)benzamide

There total 1 articles about (S)-N-(1-hydroxy-3-phenylpropan-2-yl)-3,5-bis(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 3182-95-4
L-Phenylalaninol

: 785-56-8
3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride

: 1443529-51-8
(S)-N-(1-hydroxy-3-phenylpropan-2-yl)-3,5-bis(trifluoromethyl)benzamide

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃;
DOI:10.1039/c3cc42864h

Reference yield:

: 1443529-51-8
(S)-N-(1-hydroxy-3-phenylpropan-2-yl)-3,5-bis(trifluoromethyl)benzamide

: C₁₈H₁₄BrF₆NO

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1039/c3cc42864h

Reference yield:

: 1443529-51-8
(S)-N-(1-hydroxy-3-phenylpropan-2-yl)-3,5-bis(trifluoromethyl)benzamide

: 1443529-53-0
(S)-(2-(3,5-bis(trifluoromethyl)benzamido)-3-phenylpropyl)triphenylphosphonium bromide

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; carbon tetrabromide / dichloromethane / 2 h / 0 - 20 °C

2: toluene / 12 h / Reflux

With carbon tetrabromide; triphenylphosphine; In dichloromethane; toluene;
DOI:10.1002/adsc.201300383