10-((1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

Base Information

• Chemical Name: 10-((1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one
• CAS No.: 368846-07-5
• Molecular Formula: C₂₉H₂₀ClN₃OS
• Molecular Weight: 494.016
• Mol file: 368846-07-5.mol

Synonyms:10-((1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

Chemical Property of 10-((1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-((1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

There total 4 articles about 10-((1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + 5-p-chlorophenyl-5H-2,3,6,7-tetrahydrobenzothiazolo<2,3-b>quinazoline-3-one (128483-30-7) → 10-((1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one (368846-07-5)

Guidance literature:

With piperidine; In ethanol; for 4h; Reflux;

DOI:10.1016/j.bmcl.2014.07.030

Reference yield:

2-Mercapto-4-p-chlorophenyl-4H-1,2,3,4,5,6-hexahydrobenzo-quinazoline (128483-26-1) → 10-((1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one (368846-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / Reflux

2: piperidine / ethanol / 4 h / Reflux

With piperidine; acetic acid; In ethanol; 2: |Knoevenagel Condensation;

DOI:10.1016/j.bmcl.2014.07.030

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 10-((1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one (368846-07-5)

Guidance literature:

Multi-step reaction with 3 steps

1: poly(4-vinylpyridinium)hydrogen sulfate / neat (no solvent) / 120 °C

2: acetic acid / Reflux

3: piperidine / ethanol / 4 h / Reflux

With piperidine; acetic acid; In ethanol; 1: |Biginelli Pyrimidone Synthesis / 3: |Knoevenagel Condensation;

DOI:10.1016/j.bmcl.2014.07.030

upstream raw materials:

Indole-3-carboxaldehyde

5-p-chlorophenyl-5H-2,3,6,7-tetrahydrobenzothiazolo<2,3-b>quinazoline-3-one

2-Mercapto-4-p-chlorophenyl-4H-1,2,3,4,5,6-hexahydrobenzo-quinazoline

3,4-dihydronaphthalene-1(2H)-one