(R)-α-benzyl-α-methylmalonamic acid

Base Information

• Chemical Name: (R)-α-benzyl-α-methylmalonamic acid
• CAS No.: 159835-31-1
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229

Synonyms:(R)-α-benzyl-α-methylmalonamic acid

Chemical Property of (R)-α-benzyl-α-methylmalonamic acid

Chemical Property:

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Technology Process of (R)-α-benzyl-α-methylmalonamic acid

There total 15 articles about (R)-α-benzyl-α-methylmalonamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

R-(+)-methyl 3-amino-2-benzyl-2-methyl-3-oxopropanoate (159835-34-4) → (R)-α-benzyl-α-methylmalonamic acid (159835-31-1)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 12h;

DOI:10.1016/S0968-0896(99)00110-8

Reference yield: 94.0%

α-benzyl-α-methylmalonamide (183676-97-3) → (R)-α-benzyl-α-methylmalonamic acid (159835-31-1)

Guidance literature:

With Rodococcus sp. CGMCC 0497; In phosphate buffer; at 30 ℃; for 24h; pH=7.0;

DOI:10.1021/jo026691u

Reference yield: 90.0%

α-benzyl-α-methylmalononitrile (21455-96-9) → (R)-α-benzyl-α-methylmalonamic acid (159835-31-1)

Guidance literature:

With Rhodococcus rhodochrous IFO 15564 cells; for 72h;

DOI:10.1016/j.tetasy.2004.04.047

upstream raw materials:

R-(+)-methyl 3-amino-2-benzyl-2-methyl-3-oxopropanoate

α-benzyl-α-methylmalononitrile

α-benzyl-α-methylmalonamide

(R)-(-)-2-cyano-2-methyl-3-phenylpropionic acid

Downstream raw materials:

(S)-2-ethoxycarbonylamino-2-methyl-3-phenylpropanoic acid ethyl ester

(R)-2-cyano-2-methyl-3-phenylpropionic acid ethyl ester

(S)-4-benzyl-4-methyloxazolidin-2,5-dione

R-(+)-methyl 3-amino-2-benzyl-2-methyl-3-oxopropanoate

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