1‐[(2S)‐3‐[(tert‐butyldimethylsilyl)oxy]‐2‐{[4‐(trifluoromethoxy)phenyl]methoxy}propyl]‐2‐chloro‐4‐nitro‐1H‐imidazole

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Chemical Name:1‐[(2S)‐3‐[(tert‐butyldimethylsilyl)oxy]‐2‐{[4‐(trifluoromethoxy)phenyl]methoxy}propyl]‐2‐chloro‐4‐nitro‐1H‐imidazole
CAS No.:1129692-90-5
Molecular Formula:C₂₀H₂₇ClF₃N₃O₅Si
Molecular Weight:509.985
Hs Code.:

Synonyms:1‐[(2S)‐3‐[(tert‐butyldimethylsilyl)oxy]‐2‐{[4‐(trifluoromethoxy)phenyl]methoxy}propyl]‐2‐chloro‐4‐nitro‐1H‐imidazole

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Chemical Property of 1‐[(2S)‐3‐[(tert‐butyldimethylsilyl)oxy]‐2‐{[4‐(trifluoromethoxy)phenyl]methoxy}propyl]‐2‐chloro‐4‐nitro‐1H‐imidazole

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Technology Process of 1‐[(2S)‐3‐[(tert‐butyldimethylsilyl)oxy]‐2‐{[4‐(trifluoromethoxy)phenyl]methoxy}propyl]‐2‐chloro‐4‐nitro‐1H‐imidazole

There total 4 articles about 1‐[(2S)‐3‐[(tert‐butyldimethylsilyl)oxy]‐2‐{[4‐(trifluoromethoxy)phenyl]methoxy}propyl]‐2‐chloro‐4‐nitro‐1H‐imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.12%

: 943610-37-5
(S)?1?(tert?butyldimethylsilyloxy)?3?(2?chloro?4?nitro?1H?imidazol?1?yl) propan?2?ol

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 1129692-90-5
1‐[(2S)‐3‐[(tert‐butyldimethylsilyl)oxy]‐2‐{[4‐(trifluoromethoxy)phenyl]methoxy}propyl]‐2‐chloro‐4‐nitro‐1H‐imidazole

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 4.5h; Inert atmosphere;

Reference yield:

: (S)?1?chloro?3?(2?chloro?4?nitro?1H?imidazol?1?yl)propan?2?ol

: 1129692-90-5
1‐[(2S)‐3‐[(tert‐butyldimethylsilyl)oxy]‐2‐{[4‐(trifluoromethoxy)phenyl]methoxy}propyl]‐2‐chloro‐4‐nitro‐1H‐imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / 3 h / 90 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 7.67 h / 20 °C

3: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 4.5 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: (S)?3?(2?chloro?4?nitro?1H?imidazol?1?yl)propane?1,2?diol

: 1129692-90-5
1‐[(2S)‐3‐[(tert‐butyldimethylsilyl)oxy]‐2‐{[4‐(trifluoromethoxy)phenyl]methoxy}propyl]‐2‐chloro‐4‐nitro‐1H‐imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 7.67 h / 20 °C

2: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 4.5 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;