tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

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Chemical Name:tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate
CAS No.:871657-68-0
Molecular Formula:C₂₇H₄₃N₃O₆Si
Molecular Weight:533.74
Hs Code.:

Synonyms:tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

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Chemical Property of tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

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Technology Process of tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

There total 9 articles about tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871657-69-1
tert-butyl 3-[(3-(benzyloxy)-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

: 871657-68-0
tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 6h;

Reference yield:

: 863504-84-1
3-aminopyrazole-1-carboxylic acid tert-butyl ester

: 871657-68-0
tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 6 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol;

Reference yield:

: 871657-72-6
(R)-1-(triisopropylsilyloxy)propan-2-ol

: 871657-68-0
tert-butyl 3-[(3-hydroxy-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethoxy}benzoyl)amino]-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3.75 h / 0 - 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 43 °C

2.2: pH 5

3.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 6 h / 20 °C

With lithium hydroxide; di-isopropyl azodicarboxylate; water; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol;