1-[4-(methylsulfonyl)benzyl]-4-[3-oxo-3-{3-(tert-butyldimethylsilyloxy)phenyl}propyl]homopiperazine

Base Information

• Chemical Name: 1-[4-(methylsulfonyl)benzyl]-4-[3-oxo-3-{3-(tert-butyldimethylsilyloxy)phenyl}propyl]homopiperazine
• CAS No.: 199938-51-7
• Molecular Formula: C₂₈H₄₂N₂O₄SSi
• Molecular Weight: 530.804
• Mol file: 199938-51-7.mol

Synonyms:1-[4-(methylsulfonyl)benzyl]-4-[3-oxo-3-{3-(tert-butyldimethylsilyloxy)phenyl}propyl]homopiperazine

Chemical Property of 1-[4-(methylsulfonyl)benzyl]-4-[3-oxo-3-{3-(tert-butyldimethylsilyloxy)phenyl}propyl]homopiperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(methylsulfonyl)benzyl]-4-[3-oxo-3-{3-(tert-butyldimethylsilyloxy)phenyl}propyl]homopiperazine

There total 2 articles about 1-[4-(methylsulfonyl)benzyl]-4-[3-oxo-3-{3-(tert-butyldimethylsilyloxy)phenyl}propyl]homopiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(methylsulfonyl)benzyl methanesulfonate → 1-[4-(methylsulfonyl)benzyl]-4-[3-oxo-3-{3-(tert-butyldimethylsilyloxy)phenyl}propyl]homopiperazine (199938-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / ethanol / Heating

2: CH₂Cl₂

In ethanol; dichloromethane; 2: Michael addition;

DOI:10.1016/j.bmcl.2004.08.008

Reference yield:

1-(3-((tert-butyldimethylsilyl)oxy)phenyl)prop-2-en-1-one + 1-[4-(methylsulfonyl)benzyl]homopiperazine (199928-85-3) → 1-[4-(methylsulfonyl)benzyl]-4-[3-oxo-3-{3-(tert-butyldimethylsilyloxy)phenyl}propyl]homopiperazine (199938-51-7)

Guidance literature:

In dichloromethane;

DOI:10.1016/j.bmcl.2004.08.008

Reference yield:

3,5-difluorophenylmagnesium bromide (62351-47-7) + 1-[4-(methylsulfonyl)benzyl]-4-[3-oxo-3-{3-(tert-butyldimethylsilyloxy)phenyl}propyl]homopiperazine (199938-51-7) → 1-(3,5-difluorophenyl)-3-hydroxy-3-(3-hydroxyphenyl)propyl-4-[4-(methylsulfonyl)benzyl]homopiperazine (654062-92-7)

Guidance literature:

DOI:10.1016/j.bmcl.2004.08.008

upstream raw materials:

1-[4-(methylsulfonyl)benzyl]homopiperazine

Downstream raw materials:

1-(3,5-difluorophenyl)-3-hydroxy-3-(3-hydroxyphenyl)propyl-4-[4-(methylsulfonyl)benzyl]homopiperazine