62351-47-7

Basic information

• Product Name: 3,5-DIFLUOROPHENYLMAGNESIUM BROMIDE
• Synonyms: 3,5-DIFLUOROPHENYLMAGNESIUM BROMIDE;3,5-DIFLUOROPHENYLMAGNESIUM BROMIDE, 0.5M SOLUTION IN TETRAHYDROFURAN;3,5-difluorophenylmagnesium bromide solution;3,5-Difluorophenylmagnesium bromide,0.5M solution in THF;3,5-Difluorophenylmagnesium bromide solution 0.5 in THF;3,5-Difluorophenylmagnesium bromide, 0.5M solution in THF, AcroSeal;3,5-DifluorophenylMagnesiuM broMide, 0.50M in 2-MeTHF;MagnesiuM broMide 3,5-difluorobenzenide
• CAS NO: 62351-47-7
• Molecular Formula: C₆H₃BrF₂Mg
• Molecular Weight: 217.29
• Product Categories: Aryl;Grignard Reagents;Organometallic Reagents;Chemical Synthesis;Grignard Reagents;Organometallic Reagents;Grignard Reagent
• Mol File: 62351-47-7.mol

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: <1 °F
• Appearance: /
• Density: 0.971 g/mL at 25 °C
• Vapor Pressure: 82.7mmHg at 25°C
• Storage Temp.: 2-8°C
• Sensitive: Air & Moisture Sensitive
• CAS DataBase Reference: 3,5-DIFLUOROPHENYLMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIFLUOROPHENYLMAGNESIUM BROMIDE(62351-47-7)
• EPA Substance Registry System: 3,5-DIFLUOROPHENYLMAGNESIUM BROMIDE(62351-47-7)

Safety Data

• Hazard Codes: F,C,Xn
• Statements: 11-14-19-22-34-36/37-40
• Safety Statements: 16-26-33-36/37/39-45-36/37
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• HazardClass: 3
• Hazardous Substances Data: 62351-47-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Difluorophenylmagnesium bromide is used as a starting material for the synthesis of cis-2-phenyl-1-amino-cyclopentanes, which are AMPA receptor potentiators. These potentiators play a crucial role in enhancing the activity of AMPA receptors, which are essential for cognitive function and synaptic plasticity.
Used in Organic Light-Emitting Diodes (OLEDs):
3,5-Difluorophenylmagnesium bromide is used to prepare copper(I) complexes, which serve as luminescent guest molecules in OLEDs. These complexes contribute to the development of efficient and eco-friendly lighting technologies, as well as advanced display systems.
Used in Medicinal Chemistry:
3,5-Difluorophenylmagnesium bromide is used as an intermediate in the synthesis of 2-aminoethylbenzofuran H3 receptor antagonists. These antagonists are valuable in the development of drugs targeting the H3 receptor, which is implicated in various physiological processes, including wakefulness, cognition, and energy metabolism.

InChI:InChI=1/C6H3F2.BrH.Mg/c7-5-2-1-3-6(8)4-5;;/h2-4H;1H;/q-1;;+2/p-1

Upstream product

• 461-96-1 3,5-difluorobromobenzene 

Downstream Products

• 79538-22-0 1-allyl-3,5-difluorobenzene 
• 782504-48-7 (3,5-difluorophenyl)(pyridin-4-yl)methanol 
• 957121-16-3 methyl 5-(3,5-difluorophenyl)-2,2-dimethyl-5-oxopentanoate 
• 957121-37-8 N-[(SS,1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-(3,5-difluorophenyl)ethyl]-2-methylpropane-2-sulfinamide 
• 957121-78-7 6-(3,5-difluorophenyl)-3,3-dimethylpiperidine-2,4-dione 
• 820971-68-4 tert-butyl 3-(3,5-difluorophenyl)azetidine-1-carboxylate 
• 59-31-4 2-quinolone 
• 1040544-24-8 ethyl 3-{2-[1-(3,5-difluorophenyl)-2-(ethyloxy)-2-oxoethylidene]hydrazino}-3-oxopropanoate 
• 718611-14-4 (4S,5R)-1-[(R)-3-(4-methanesulphonyl-phenyl)-3-(3,5-di-fluorophenyl)-propionyl]-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 138074-23-4 trans-4-pentyl-trans-4'-(3,5-difluorophenyl)-1,1'-bi(cyclohexyl) 
• 138074-23-4 trans-4-pentyl-cis-4'-(3,5-difluorophenyl)-1,1'-bi(cyclohexyl) 
• 1146593-99-8 (3,5-difluorophenyl)cycloheptane 
• 32085-88-4 3,5-difluorobenzaldehyde 
• 159418-72-1 bis(3,5-difluorophenyl)chlorophosphine 

Relevant articles and documents

Room-Temperature Palladium(II)-Catalyzed Direct 2-Arylation of Indoles with Tetraarylstannanes

A palladium(II)-catalyzed direct 2-arylation of indoles by tetraarylstannanes with oxygen (balloon) as the oxidant at room temperature has been developed. Various tetraarylstannanes can be employed as aryl sources for 2-arylation of indoles in up to 89% yield, providing a practical and efficient catalytic protocol for accessing 2-arylindoles.

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