[4-(3-{4'-[3-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester

Base Information

• Chemical Name: [4-(3-{4'-[3-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester
• CAS No.: 719293-47-7
• Molecular Formula: C₄₀H₄₀F₆O₆S₂
• Molecular Weight: 794.876
• Mol file: 719293-47-7.mol

Synonyms:[4-(3-{4'-[3-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester

Chemical Property of [4-(3-{4'-[3-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(3-{4'-[3-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester

There total 7 articles about [4-(3-{4'-[3-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

3-[4'-(3-hydroxy-propyl)-2,2'-bis-trifluoromethyl-biphenyl-4-yl]-propan-1-ol (719293-72-8) + (4-mercapto-2-methyl-phenoxy)-acetic acid methyl ester (56077-47-5) → [4-(3-{4'-[3-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester (719293-47-7)

Guidance literature:

3-[4'-(3-hydroxy-propyl)-2,2'-bis-trifluoromethyl-biphenyl-4-yl]-propan-1-ol; With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 0 ℃; for 0.166667h;

(4-mercapto-2-methyl-phenoxy)-acetic acid methyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

2,2'-bis(trifluoromethyl)-4,4'-diiodobiphenyl (89803-70-3) → [4-(3-{4'-[3-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester (719293-47-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / palladium diacetate; triphenylphosphine / DMF (N,N-dimethyl-formamide) / 5 h / 110 °C / Heating / reflux

2.1: sodium tetrahydroborate / polyethylene glycol (PEG 400) / 6.5 h / 130 °C

3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.17 h / 0 °C

3.2: 3 h / 0 - 20 °C

With sodium tetrahydroborate; tributylphosphine; triethylamine; 1,1'-azodicarbonyl-dipiperidine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); polyethylene glycol (PEG 400);

Reference yield:

2,2'-bis(trifluoromethyl)benzidine (341-58-2) → [4-(3-{4'-[3-(4-methoxycarbonylmethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester (719293-47-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid; sodium nitrite / water; acetic acid / 1 h / 5 °C

1.2: 3 h

2.1: triethylamine / palladium diacetate; triphenylphosphine / DMF (N,N-dimethyl-formamide) / 5 h / 110 °C / Heating / reflux

3.1: sodium tetrahydroborate / polyethylene glycol (PEG 400) / 6.5 h / 130 °C

4.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.17 h / 0 °C

4.2: 3 h / 0 - 20 °C

With sodium tetrahydroborate; tributylphosphine; sulfuric acid; triethylamine; 1,1'-azodicarbonyl-dipiperidine; sodium nitrite; palladium diacetate; triphenylphosphine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); polyethylene glycol (PEG 400); water; acetic acid;

upstream raw materials:

3-[4'-(3-hydroxy-propyl)-2,2'-bis-trifluoromethyl-biphenyl-4-yl]-propan-1-ol

(4-mercapto-2-methyl-phenoxy)-acetic acid methyl ester

2,2'-bis(trifluoromethyl)-4,4'-diiodobiphenyl

2,2'-bis(trifluoromethyl)benzidine

Downstream raw materials:

[4-(3-{4'-[3-(4-carboxymethoxy-3-methyl-phenylsulfanyl)-propyl]-2,2'-bis-trifluoromethyl-biphenyl-4-yl}-propylsulfanyl)-2-methyl-phenoxy]-acetic acid