N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-threonyl-O-(phenylmethyl)-L-serine (1R)-1-[(1R,2S,3S)-2,4-dihydroxy-1,3-dimethylbutyl]tetradecyl ester

Base Information

Chemical Name:N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-threonyl-O-(phenylmethyl)-L-serine (1R)-1-[(1R,2S,3S)-2,4-dihydroxy-1,3-dimethylbutyl]tetradecyl ester
CAS No.:467224-49-3
Molecular Formula:C₄₄H₇₇N₃O₁₀
Molecular Weight:808.109
Hs Code.:

Synonyms:N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-threonyl-O-(phenylmethyl)-L-serine (1R)-1-[(1R,2S,3S)-2,4-dihydroxy-1,3-dimethylbutyl]tetradecyl ester

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Chemical Property of N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-threonyl-O-(phenylmethyl)-L-serine (1R)-1-[(1R,2S,3S)-2,4-dihydroxy-1,3-dimethylbutyl]tetradecyl ester

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Technology Process of N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-threonyl-O-(phenylmethyl)-L-serine (1R)-1-[(1R,2S,3S)-2,4-dihydroxy-1,3-dimethylbutyl]tetradecyl ester

There total 23 articles about N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-threonyl-O-(phenylmethyl)-L-serine (1R)-1-[(1R,2S,3S)-2,4-dihydroxy-1,3-dimethylbutyl]tetradecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 467224-48-2
(S)-3-Benzyloxy-2-[(2S,3R)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-butyrylamino]-propionic acid (R)-1-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetradecyl ester

: 467224-49-3
N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-threonyl-O-(phenylmethyl)-L-serine (1R)-1-[(1R,2S,3S)-2,4-dihydroxy-1,3-dimethylbutyl]tetradecyl ester

Guidance literature:: With acetic acid; In water; at 20 ℃; for 10h;
DOI:10.1039/b202298b

Reference yield: 94.0%

: N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-threonyl-O-(phenylmethyl)-L-serine (1R)-1-[(1S)-1-[(4S,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl]ethyl]tetradecyl ester

: 467224-49-3
N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-threonyl-O-(phenylmethyl)-L-serine (1R)-1-[(1R,2S,3S)-2,4-dihydroxy-1,3-dimethylbutyl]tetradecyl ester

Guidance literature:: With acetic acid; In water; at 20 ℃; for 10h;
DOI:10.1246/bcsj.79.921

Reference yield:

: 69541-82-8
N-(tert-butoxycarbonyl)valine-O-benzyl-L-threonine benzyl ester

: 467224-49-3
N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-threonyl-O-(phenylmethyl)-L-serine (1R)-1-[(1R,2S,3S)-2,4-dihydroxy-1,3-dimethylbutyl]tetradecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / H₂ / Pd on carbon / ethanol / 4 h / 20 °C / atmospheric pressure

2: 22.9 mg / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 14 h / 20 °C

3: 94 percent / acetic acid / H₂O / 10 h / 20 °C

With hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.79.921