2,2,2-TRIFLUORO-2',4',6'-TRIMETHYLACETOPHENONE

Base Information

• Chemical Name: 2,2,2-TRIFLUORO-2',4',6'-TRIMETHYLACETOPHENONE
• CAS No.: 313-56-4
• Molecular Formula: C11H11 F3 O
• Molecular Weight: 216.203
• Hs Code.: 2914700090
• Mol file: 313-56-4.mol

Synonyms:1,3,5-Trimethyl-4-(trifluoroacetyl)benzene;Mesityl trifluoromethyl ketone

Chemical Property of 2,2,2-TRIFLUORO-2',4',6'-TRIMETHYLACETOPHENONE

Chemical Property:

• Refractive Index: n20/D 1.456(lit.)
• Boiling Point: 236.3°Cat760mmHg
• Flash Point: 113.7°C
• PSA: 17.07000
• Density: 1.161g/cm³
• LogP: 3.35680

Purity/Quality:

97% ^*data from raw suppliers

2,2,2-Trifluoro-2',4',6'-trimethylacetophenone 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,F
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,2,2-Trifluoro-2′,4′,6′-trimethylacetophenone may be used for organic synthesis.

Technology Process of 2,2,2-TRIFLUORO-2',4',6'-TRIMETHYLACETOPHENONE

There total 4 articles about 2,2,2-TRIFLUORO-2',4',6'-TRIMETHYLACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-(2,4,6-trimethylphenyl)-2,2,2-trifluoroethanol (102626-53-9) → α,α,α-trifluoro-2,4,6-trimethylacetophenone (313-56-4)

Guidance literature:

With 9-azabicyclo[3.3.1]nonan-3-one N-oxyl oxide; oxygen; acetic acid; sodium nitrite; at 20 ℃; for 18h; under 760.051 Torr; chemoselective reaction;

DOI:10.1002/adsc.201500131

Reference yield:

ethyl trifluoroacetate, (383-63-1) + 2,4,6-trimethylphenyl bromide (576-83-0) → α,α,α-trifluoro-2,4,6-trimethylacetophenone (313-56-4)

Guidance literature:

With tert.-butyl lithium; Yield given. Multistep reaction; 2) ether, -78 deg C to room temperature;

DOI:10.1021/jo00002a082

Reference yield:

2,4,6-trimethylphenyl bromide (576-83-0) + trifluoroacetic anhydride (407-25-0) → α,α,α-trifluoro-2,4,6-trimethylacetophenone (313-56-4)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) ether, hexanes, 23 deg C, 18 h, 2) -40 deg C, 30 min;

DOI:10.1016/0040-4039(91)80419-7

upstream raw materials:

ethyl trifluoroacetate,

2,4,6-trimethylphenyl bromide

trifluoroacetic anhydride

1-(2,4,6-trimethylphenyl)-2,2,2-trifluoroethanol

Downstream raw materials:

(E)-ethyl 2,4,4,4-tetrafluoro-3-mesitylbut-2-enoate

(Z)-ethyl 2,4,4,4-tetrafluoro-3-mesitylbut-2-enoate

(S)-Methoxy-phenyl-acetic acid (S)-2,2,2-trifluoro-1-(2,4,6-trimethyl-phenyl)-ethyl ester

(S)-Methoxy-phenyl-acetic acid (R)-2,2,2-trifluoro-1-(2,4,6-trimethyl-phenyl)-ethyl ester

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