2-(2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl))ethylaminoadenosine-5'-N-ethylcarboxamide

Base Information

Chemical Name:2-(2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl))ethylaminoadenosine-5'-N-ethylcarboxamide
CAS No.:1365619-31-3
Molecular Formula:C₃₅H₄₆N₈O₅
Molecular Weight:658.801
Hs Code.:

Synonyms:2-(2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl))ethylaminoadenosine-5'-N-ethylcarboxamide

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Chemical Property of 2-(2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl))ethylaminoadenosine-5'-N-ethylcarboxamide

Chemical Property:

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Technology Process of 2-(2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl))ethylaminoadenosine-5'-N-ethylcarboxamide

There total 5 articles about 2-(2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl))ethylaminoadenosine-5'-N-ethylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1365619-27-7
2-(2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl))ethylamino-2',3'-isopropylideneadenosine-5'-N-ethylcarboxamide

: 1365619-31-3
2-(2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl))ethylaminoadenosine-5'-N-ethylcarboxamide

Guidance literature:: With hydrogenchloride; water; In acetonitrile; at 60 ℃; for 8h;
DOI:10.1021/jm300206u

Reference yield:

: 13472-00-9
p-Aminophenethylamine

: 1365619-31-3
2-(2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl))ethylaminoadenosine-5'-N-ethylcarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 0.75 h / -5 - 0 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 25 °C

3: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

4: N-ethyl-N,N-diisopropylamine / ethanol / 120 h / 70 °C

5: hydrogenchloride; water / acetonitrile / 8 h / 60 °C

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300206u

Reference yield:

: 1365619-24-4
N-(tert-butoxycarbonyl)-2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl)ethylamine

: 1365619-31-3
2-(2-(4-N-(3,5-di-tert-butylphenylcarboxy)aminophenyl))ethylaminoadenosine-5'-N-ethylcarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / 120 h / 70 °C

3: hydrogenchloride; water / acetonitrile / 8 h / 60 °C

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm300206u