(4R,5S)-5-(benzyloxy)-4-[1-(tert-butyl)-1,1-dimethylsilyl]oxyhexanoic acid

Base Information

Chemical Name:(4R,5S)-5-(benzyloxy)-4-[1-(tert-butyl)-1,1-dimethylsilyl]oxyhexanoic acid
CAS No.:959774-89-1
Molecular Formula:C₁₉H₃₂O₄Si
Molecular Weight:352.546
Hs Code.:

Synonyms:(4R,5S)-5-(benzyloxy)-4-[1-(tert-butyl)-1,1-dimethylsilyl]oxyhexanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-5-(benzyloxy)-4-[1-(tert-butyl)-1,1-dimethylsilyl]oxyhexanoic acid

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Technology Process of (4R,5S)-5-(benzyloxy)-4-[1-(tert-butyl)-1,1-dimethylsilyl]oxyhexanoic acid

There total 2 articles about (4R,5S)-5-(benzyloxy)-4-[1-(tert-butyl)-1,1-dimethylsilyl]oxyhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 959774-96-0
ethyl (4R,5S)-5-(benzyloxy)-4-[1-(tert-butyl)-1,1-dimethylsilyl]oxyhexanoate

: 959774-89-1
(4R,5S)-5-(benzyloxy)-4-[1-(tert-butyl)-1,1-dimethylsilyl]oxyhexanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h;
DOI:10.1016/j.tetasy.2007.08.017

Reference yield:

: ethyl (4R,5S)-5-(benzyloxy)-4-[1-(tert-butyl)-1,1-dimethylsilyl]oxy-2-hexenoate

: 959774-89-1
(4R,5S)-5-(benzyloxy)-4-[1-(tert-butyl)-1,1-dimethylsilyl]oxyhexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / PtO₂ / ethyl acetate / 3 h / 20 °C

2: 82 percent / LiOH / H₂O; tetrahydrofuran; methanol / 4 h / 20 °C

With lithium hydroxide; hydrogen; platinum(IV) oxide; In tetrahydrofuran; methanol; water; ethyl acetate;
DOI:10.1016/j.tetasy.2007.08.017