3-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-methoxy-benzenesulfonamide; hydrochloride

Base Information

Chemical Name:3-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-methoxy-benzenesulfonamide; hydrochloride
CAS No.:74832-03-4
Molecular Formula:C₁₉H₂₆N₂O₄S*ClH
Molecular Weight:414.953
Hs Code.:

Synonyms:3-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-methoxy-benzenesulfonamide; hydrochloride

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Chemical Property of 3-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-methoxy-benzenesulfonamide; hydrochloride

Chemical Property:

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Technology Process of 3-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-methoxy-benzenesulfonamide; hydrochloride

There total 8 articles about 3-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-methoxy-benzenesulfonamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 344751-92-4
3-{2-[Benzyl-(1-methyl-3-phenyl-propyl)-amino]-1-hydroxy-ethyl}-2-methoxy-benzenesulfonamide

: 74832-03-4
3-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-methoxy-benzenesulfonamide; hydrochloride

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;
DOI:10.1248/cpb.30.4092

Reference yield:

: 79406-57-8
3-amino-4-chloroacetophenone

: 74832-03-4
3-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-methoxy-benzenesulfonamide; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaNO₂, cc HCl 2.) CuCl₂*2H₂O, SO₂ / 1.) AcOH, 5 deg C, 30 min 2.) AcOH, 0-5 deg C

2: cc NH₄OH / tetrahydrofuran / Ambient temperature

3: 64 percent / 0.25 h / Heating

4: 80 percent / chlorine / aq. acetic acid / 5 °C

5: 34 percent / Bromine / acetic acid / 0.5 h / Ambient temperature

6: butan-2-one / 4 h / Heating

7: NaBH₄ / methanol / 2 h / Ambient temperature

8: 23 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; sulfur dioxide; hydrogen; bromine; chlorine; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; butanone;
DOI:10.1248/cpb.30.4092

Reference yield:

: 2350-44-9
4'-chloro-3'-sulfamoyl-acetophenone

: 74832-03-4
3-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-methoxy-benzenesulfonamide; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / 0.25 h / Heating

2: 80 percent / chlorine / aq. acetic acid / 5 °C

3: 34 percent / Bromine / acetic acid / 0.5 h / Ambient temperature

4: butan-2-one / 4 h / Heating

5: NaBH₄ / methanol / 2 h / Ambient temperature

6: 23 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; bromine; chlorine; palladium on activated charcoal; In methanol; acetic acid; butanone;
DOI:10.1248/cpb.30.4092