2-(2-(3-chloro-4-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid ethyl ester

Base Information

Chemical Name:2-(2-(3-chloro-4-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid ethyl ester
CAS No.:1242850-27-6
Molecular Formula:C₁₈H₂₁ClN₂O₄S
Molecular Weight:396.895
Hs Code.:

Synonyms:2-(2-(3-chloro-4-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid ethyl ester

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Chemical Property of 2-(2-(3-chloro-4-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid ethyl ester

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Technology Process of 2-(2-(3-chloro-4-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid ethyl ester

There total 5 articles about 2-(2-(3-chloro-4-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242850-14-1
C₁₁H₁₆N₂O₂

: 42413-03-6
3-chloro-4-methylbenzenesulfonyl chloride

: 1242850-27-6
2-(2-(3-chloro-4-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; Inert atmosphere;

Reference yield:

: 29709-35-1
1-(2-aminoethyl)pyrrole

: 1242850-27-6
2-(2-(3-chloro-4-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: polyphosphoric acid / 5 h / 90 °C

3: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 1500.15 Torr

4: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere

With 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

Reference yield:

: 1242850-13-0
C₁₁H₁₄N₂O₂

: 1242850-27-6
2-(2-(3-chloro-4-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 1500.15 Torr

2: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;