42413-03-6

Basic information

• Product Name: 3-CHLORO-4-METHYLBENZENESULFONYL CHLORIDE
• Synonyms: BUTTPARK 95\57-32;3-CHLORO-4-METHYLBENZENE-1-SULFONYL CHLORIDE;3-CHLORO-4-METHYLBENZENESULPHONYL CHLORIDE;3-CHLORO-4-METHYLBENZENESULFONYL CHLORIDE;3-Chloro-p-toluenesulphonyl chloride;3-chloro-p-toluenesulfonyl chloride;3-Chloro-4-methylbenzenesulphonyl chloride 98%;2-chloro-p-toluenesulfochloride
• CAS NO: 42413-03-6
• Molecular Formula: C₇H₆Cl₂O₂S
• Molecular Weight: 225.09
• EINECS: 412-890-1
• Product Categories: Miscellaneous;Benzenesulfonyl chloride;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 42413-03-6.mol

Chemical Properties

• Melting Point: 34-38 °C(lit.)
• Boiling Point: 125 °C
• Flash Point: >230 °F
• Appearance: /
• Density: 1.458
• Vapor Pressure: 0.00146mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Moisture Sensitive
• BRN: 2364094
• CAS DataBase Reference: 3-CHLORO-4-METHYLBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-METHYLBENZENESULFONYL CHLORIDE(42413-03-6)
• EPA Substance Registry System: 3-CHLORO-4-METHYLBENZENESULFONYL CHLORIDE(42413-03-6)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-43-52/53
• Safety Statements: 23-26-36/37/39-45-61
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 2
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 42413-03-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Chloro-4-methylbenzenesulfonyl chloride is used as a synthetic intermediate for the production of various pharmaceutical compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable building block in the development of new drugs.
Used in the Synthesis of 2-chloro 4-methylsulfonamide benzylamine:
Specifically, 3-Chloro-4-methylbenzenesulfonyl chloride is utilized in the synthesis of 2-chloro 4-methylsulfonamide benzylamine, a compound that may have potential applications in the pharmaceutical industry. The sulfonyl chloride group in this intermediate is particularly useful for further functionalization and modification of the target molecule.

InChI:InChI=1/C7H6Cl2O2S/c1-5-2-3-6(4-7(5)8)12(9,10)11/h2-4H,1H3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 98-34-0 3-chloro-4-methylbenzenesulfonic acid 

Downstream Products

• 24653-79-0 4-methyl-3,5-dichlorobenzenesulfonyl chloride 
• 95-49-8 2-methylchlorobenzene 
• 877-11-2 pentachlorotoluene 
• 51896-27-6 3-chloro-4-methylbenzenesulfonamide 
• 1161343-12-9 N-(benzo[d]thiazol-2-yl)-3-chloro-4-methylbenzenesulfonamide 
• 1242850-27-6 2-(2-(3-chloro-4-methylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid ethyl ester 

Relevant articles and documents

AMINOSULPHONYL- OR AMINOSULPHONYLAMINO-SUBSTITUTED PHENYL ESTERS AS ESTRIOL AND ESTETROL PRODRUGS

The invention relates to estriol and estetrol prodrugs of general formula (I), in which group Y is bonded to the steroid, the method for production thereof, pharmaceutical compositions comprising said compounds and the use thereof for production of medicaments with estrogenic effect.

Estradiol prodrugs

The invention relates to estradiol prodrugs of general formula (I), in which group Z is bonded to the steroid, process for their production, pharmaceutical compositions that contain these compounds, as well as their use for the production of pharmaceutica

Steroid prodrugs with androgenic action

This invention relates to steroid prodrugs with androgenic action of general formula (I), in which group Z is bonded to the steroid, pharmaceutical compositions that contain these compounds as well as their use for the production of pharmaceutical agents with androgenic action.

Estriol and estetrol prodrugs

This invention provides estriol and estetrol prodrugs of general formula (I), in which group Y is bonded to the steroid process for their production, pharmaceutical compositions that contain these compounds, as well as their use for the production of pharmaceutical agents with estrogenic action.

AMINOSULPHONYL- OR AMINOSULPHONYLAMINO-SUBSTITUTED PHENYL ESTERS AS ESTRADIOL PRODRUGS

The invention relates to estradiol prodrugs of general formula (I), in which the group Z is bonded to the steroid. The invention further relates to methods for production thereof, pharamceutical compositions comprising said compounds and use thereof for the production of medicaments with an estrogenic effect.

STEROID PRODRUGS WITH ANDROGENIC EFFECT

The invention relates to steroid prodrugs with androgenic effect of general formula (I), in which the group Z is bonded to the steroid, pharmaceutical compositions comprising said compounds and the use thereof for the production of medicaments with androgenic effect.