Methanesulfonic acid 3-[(3,5-bis-{[(3-methanesulfonyloxy-propyl)-(toluene-4-sulfonyl)-amino]-methyl}-benzyl)-(toluene-4-sulfonyl)-amino]-propyl ester

Base Information

• Chemical Name: Methanesulfonic acid 3-[(3,5-bis-{[(3-methanesulfonyloxy-propyl)-(toluene-4-sulfonyl)-amino]-methyl}-benzyl)-(toluene-4-sulfonyl)-amino]-propyl ester
• CAS No.: 109789-74-4
• Molecular Formula: C₄₂H₅₇N₃O₁₅S₆
• Molecular Weight: 1036.32
• Mol file: 109789-74-4.mol

Synonyms:Methanesulfonic acid 3-[(3,5-bis-{[(3-methanesulfonyloxy-propyl)-(toluene-4-sulfonyl)-amino]-methyl}-benzyl)-(toluene-4-sulfonyl)-amino]-propyl ester

Chemical Property of Methanesulfonic acid 3-[(3,5-bis-{[(3-methanesulfonyloxy-propyl)-(toluene-4-sulfonyl)-amino]-methyl}-benzyl)-(toluene-4-sulfonyl)-amino]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 3-[(3,5-bis-{[(3-methanesulfonyloxy-propyl)-(toluene-4-sulfonyl)-amino]-methyl}-benzyl)-(toluene-4-sulfonyl)-amino]-propyl ester

There total 5 articles about Methanesulfonic acid 3-[(3,5-bis-{[(3-methanesulfonyloxy-propyl)-(toluene-4-sulfonyl)-amino]-methyl}-benzyl)-(toluene-4-sulfonyl)-amino]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C39H51N3O9S3 (109774-73-4) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid 3-[(3,5-bis-{[(3-methanesulfonyloxy-propyl)-(toluene-4-sulfonyl)-amino]-methyl}-benzyl)-(toluene-4-sulfonyl)-amino]-propyl ester (109789-74-4)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 25 ℃; for 2h;

DOI:10.1016/S0040-4039(00)85349-6

Reference yield:

3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol (13379-98-1) → Methanesulfonic acid 3-[(3,5-bis-{[(3-methanesulfonyloxy-propyl)-(toluene-4-sulfonyl)-amino]-methyl}-benzyl)-(toluene-4-sulfonyl)-amino]-propyl ester (109789-74-4)

Guidance literature:

Multi-step reaction with 4 steps

2: 79 percent / K₂CO₃ / acetonitrile / 24 h / 80 °C

3: 90 percent / MeOH / pTsOH / 1 h / Ambient temperature

4: 98 percent / Et₃N / CH₂Cl₂ / 2 h / -78 - 25 °C

With methanol; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)85349-6

Reference yield:

4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide (109774-82-5) → Methanesulfonic acid 3-[(3,5-bis-{[(3-methanesulfonyloxy-propyl)-(toluene-4-sulfonyl)-amino]-methyl}-benzyl)-(toluene-4-sulfonyl)-amino]-propyl ester (109789-74-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / K₂CO₃ / acetonitrile / 24 h / 80 °C

2: 90 percent / MeOH / pTsOH / 1 h / Ambient temperature

3: 98 percent / Et₃N / CH₂Cl₂ / 2 h / -78 - 25 °C

With methanol; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)85349-6

upstream raw materials:

C₃₉H₅₁N₃O₉S₃

methanesulfonyl chloride

3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

4-methyl-N-<3-<(tetrahydro-2H-pyran-2-yl)oxy>propyl>benzenesulfonamide

Downstream raw materials:

C₆₉H₇₈N₆O₁₂S₆

C₂₇H₄₂N₆*6C₇H₈O₃S