methyl 5-[4-(4-fluorophenyl)-1-piperazinyl]-2-(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate

Base Information

Chemical Name:methyl 5-[4-(4-fluorophenyl)-1-piperazinyl]-2-(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate
CAS No.:112249-92-0
Molecular Formula:C₂₆H₃₂FN₃O₅
Molecular Weight:485.556
Hs Code.:

Synonyms:methyl 5-[4-(4-fluorophenyl)-1-piperazinyl]-2-(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 5-[4-(4-fluorophenyl)-1-piperazinyl]-2-(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate

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Technology Process of methyl 5-[4-(4-fluorophenyl)-1-piperazinyl]-2-(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate

There total 4 articles about methyl 5-[4-(4-fluorophenyl)-1-piperazinyl]-2-(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.1%

: 50995-48-7
methyl 2,5-dibromovalerate

: 6240-80-8
1-nitro-5,6,7,8-tetrahydronaphthalen-2-ol

: 112249-80-6
methyl 5-bromo-2-(2-nitrophenoxy)valerate

: 112249-91-9
methyl 5-bromo-2(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate

: 112249-92-0
methyl 5-[4-(4-fluorophenyl)-1-piperazinyl]-2-(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate

Guidance literature:

Reference yield:

: 112249-91-9
methyl 5-bromo-2(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 112249-92-0
methyl 5-[4-(4-fluorophenyl)-1-piperazinyl]-2-(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1248/cpb.39.2896

Reference yield:

: 1125-78-6
5,6,7,8-Tetrahydro-2-naphthol

: 112249-92-0
methyl 5-[4-(4-fluorophenyl)-1-piperazinyl]-2-(5,6,7,8-tetrahydro-1-nitro-2-naphthyloxy)valerate

Guidance literature:: Multi-step reaction with 3 steps

1: 45.9 percent / NaNO₃, La(NO₃)3*6H₂O, 6 N HCl / diethyl ether / 20 h / Ambient temperature

2: K₂CO₃ / dimethylformamide / Ambient temperature

3: NEt₃ / dimethylformamide / 80 °C

With hydrogenchloride; sodium nitrate; potassium carbonate; lanthanum(III) nitrate; triethylamine; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2896