2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide

Base Information

Chemical Name:2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide
CAS No.:1285515-56-1
Molecular Formula:C₂₄H₂₁F₂N₃O₄
Molecular Weight:453.445
Hs Code.:

Synonyms:2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide

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Chemical Property of 2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide

Chemical Property:

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Technology Process of 2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide

There total 6 articles about 2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285517-99-8
2-{[(4-fluorophenyl)methyl]oxy}-5-(4-morpholinylcarbonyl)benzoic acid

: 1597-33-7
2-fluoro-3-pyridinylamine

: 1285515-56-1
2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 41489-76-3
methyl-5-formyl-2-hydroxybenzoate

: 1285515-56-1
2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 0.75 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: caesium carbonate / acetone / 2 h / 50 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 50 °C

4.2: Cooling

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With sodium chlorite; aminosulfonic acid; water; benzotriazol-1-ol; caesium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 1285515-56-1
2-{[(4-fluorophenyl)methyl]oxy}-N-(2-fluoro-3-pyridinyl)-5-(4-morpholinylcarbonyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 18 h / 50 °C

2.1: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 0.75 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: caesium carbonate / acetone / 2 h / 50 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 50 °C

5.2: Cooling

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With sodium chlorite; sulfuric acid; aminosulfonic acid; water; benzotriazol-1-ol; caesium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;