(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Base Information

Chemical Name:(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide
CAS No.:1616246-32-2
Molecular Formula:C₂₄H₃₁N₃O₃
Molecular Weight:409.528
Hs Code.:

Synonyms:(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Suppliers and Price of (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

There total 5 articles about (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.8%

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: (S)-3-amino-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxylpropyl)benzamide

: 1616246-32-2
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Guidance literature:: Tetrahydro-4H-pyran-4-one; (S)-3-amino-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxylpropyl)benzamide; With acetic acid; In methanol; at 25 ℃; for 2h;

With sodium cyanoborohydride; In methanol; at 25 ℃; for 2h;
DOI:10.1021/acsmedchemlett.5b00380

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1616246-32-2
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

2.1: ammonia / ethanol / 3 h / 80 °C / Sealed tube

3.1: ethanol / 3 h / 120 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

5.1: acetic acid / methanol / 2 h / 25 °C

5.2: 2 h / 25 °C

With potassium fluoride; ammonia; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/acsmedchemlett.5b00380

Reference yield:

: 1616077-51-0
(S)-1-amino-3-(3,4-dihydroisoquinolin-2(1H)-yl)-propan-2-ol

: 1616246-32-2
(S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 3 h / 120 °C / Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

3.1: acetic acid / methanol / 2 h / 25 °C

3.2: 2 h / 25 °C

With acetic acid; trifluoroacetic acid; In methanol; ethanol; dichloromethane;
DOI:10.1021/acsmedchemlett.5b00380