(+/-)-4,5-dihydro-2-(methylthio)-4-phenyl-3H-1,3-benzodiazepine hydroiodide

Base Information

Chemical Name:(+/-)-4,5-dihydro-2-(methylthio)-4-phenyl-3H-1,3-benzodiazepine hydroiodide
CAS No.:88057-51-6
Molecular Formula:C₁₆H₁₆N₂S*HI
Molecular Weight:396.295
Hs Code.:

Synonyms:(+/-)-4,5-dihydro-2-(methylthio)-4-phenyl-3H-1,3-benzodiazepine hydroiodide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-4,5-dihydro-2-(methylthio)-4-phenyl-3H-1,3-benzodiazepine hydroiodide

Chemical Property:

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Technology Process of (+/-)-4,5-dihydro-2-(methylthio)-4-phenyl-3H-1,3-benzodiazepine hydroiodide

There total 2 articles about (+/-)-4,5-dihydro-2-(methylthio)-4-phenyl-3H-1,3-benzodiazepine hydroiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 88057-50-5
(+/-)-1,3,4,5-tetrahydro-4-phenyl-2H-1,3-benzodiazepine-2-thione

: 74-88-4
methyl iodide

: 88057-51-6
(+/-)-4,5-dihydro-2-(methylthio)-4-phenyl-3H-1,3-benzodiazepine hydroiodide

Guidance literature:: In 2-methoxy-ethanol; Ambient temperature;
DOI:10.1021/jm00369a029

Reference yield:

: 75842-16-9
(+/-)-2-amino-α-phenylbenzeneethanamine

: 88057-51-6
(+/-)-4,5-dihydro-2-(methylthio)-4-phenyl-3H-1,3-benzodiazepine hydroiodide

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / concd HCl / aq. ethanol / 1.) 60 deg C, 1 h, 2.) reflux, 24 h

2: 79 percent / 2-methoxy-ethanol / Ambient temperature

With hydrogenchloride; In ethanol; 2-methoxy-ethanol;
DOI:10.1021/jm00369a029