3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline

Base Information

Chemical Name:3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline
CAS No.:145222-89-5
Molecular Formula:C₃₂H₃₅NO₃Si
Molecular Weight:509.72
Hs Code.:

3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopent<g>isoquinoline

Synonyms:3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline

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Chemical Property of 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline

Chemical Property:

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Technology Process of 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline

There total 7 articles about 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 145222-88-4
3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6,7-dihydro-1,9-dimethoxy-8H-cyclopentisoquinolin-8-one

: 19493-09-5
Methylenetriphenylphosphorane

: 145222-89-5
3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline

Guidance literature:: In 1,4-dioxane; for 0.5h; Ambient temperature;
DOI:10.1039/c39920001489

Reference yield:

: 145222-84-0
ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-methyl-3-pyridinecarboxylate

: 145222-89-5
3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 30 min

2: NaH, EtOH / tetrahydrofuran / 3 h / 0 °C

3: DDQ / benzene / 0.5 h / Ambient temperature

4: 1.) DEAD, Ph₃P / 1.) THF, -78 deg C, 15 min, 2.) THF, overnight

5: 1.) t-BuOK / 1.) THF, 30 min, 2.) THF, RT, 30 min

With ethanol; potassium tert-butylate; sodium hydride; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; benzene;
DOI:10.1021/ja00104a009

Reference yield:

: 145222-85-1
ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate

: 145222-89-5
3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: NaH, EtOH / tetrahydrofuran / 3 h / 0 °C

2: DDQ / benzene / 0.5 h / Ambient temperature

3: 1.) DEAD, Ph₃P / 1.) THF, -78 deg C, 15 min, 2.) THF, overnight

4: 1.) t-BuOK / 1.) THF, 30 min, 2.) THF, RT, 30 min

With ethanol; potassium tert-butylate; sodium hydride; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; diethylazodicarboxylate; In tetrahydrofuran; benzene;
DOI:10.1021/ja00104a009