6-(3-Methoxyphenyl)-1,3-dihydroindol-2-one

Base Information

• Chemical Name: 6-(3-Methoxyphenyl)-1,3-dihydroindol-2-one
• CAS No.: 215433-89-9
• Molecular Formula: C15H13 N O2
• Molecular Weight: 239.274
• DSSTox Substance ID: DTXSID30442136
• Mol file: 215433-89-9.mol

Synonyms:215433-89-9;6-(3-methoxyphenyl)-1,3-dihydroindol-2-one;6-(3-Methoxyphenyl)indolin-2-one;6-(3-METHOXY-PHENYL)-1,3-DIHYDRO-INDOL-2-ONE;6-(3-methoxyphenyl)-1,3-dihydro-indol-2-one;SCHEMBL4406856;6-(3-methoxypheny)-2-oxindole;6-(3-methoxyphenyl)-2-oxindole;DTXSID30442136;IRQBUMYFAYXEGV-UHFFFAOYSA-N;6-(3-methoxy-phenyl)-2-oxindole;6-(3-methoxyphenyl)-2,3-dihydro-1H-indol-2-one

Chemical Property of 6-(3-Methoxyphenyl)-1,3-dihydroindol-2-one

Chemical Property:

• PSA: 41.82000
• LogP: 2.94190
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 239.094628657
• Heavy Atom Count: 18
• Complexity: 318

Purity/Quality:

98%Min ^*data from raw suppliers

6-(3-methoxy-phenyl)-1,3-dihydro-indol-2-one 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C2=CC3=C(CC(=O)N3)C=C2

Technology Process of 6-(3-Methoxyphenyl)-1,3-dihydroindol-2-one

There total 8 articles about 6-(3-Methoxyphenyl)-1,3-dihydroindol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(3'-methoxy-3-nitro-biphenyl-4-yl)-acetic acid (245035-81-8) → 6-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-indole (215433-89-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jm9904295

Reference yield:

pyrographite (7440-44-0) + (3'-methoxy-3-nitro-biphenyl-4-yl)-acetic acid (245035-81-8) → 6-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-indole (215433-89-9)

Guidance literature:

palladium; In methanol;

Reference yield:

4-Bromo-1-fluoro-2-nitrobenzene (364-73-8) → 6-(3-methoxy-phenyl)-2-oxo-1,2-dihydro-indole (215433-89-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: (Ph₃P)4Pd; NaHCO₃ / toluene / 2 h / Heating

2.1: NaH; DMSO / 0.58 h / 100 °C

2.2: dimethylsulfoxide / 1 h / 100 °C

3.1: 6 N aq. HCl / 96 h / 110 °C

4.1: 73 percent / H₂ / 10 percent Pd/C / methanol / 3 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hydride; sodium hydrogencarbonate; dimethyl sulfoxide; palladium on activated charcoal; In methanol; toluene; 1.1: Suzuki coupling / 2.1: Metallation / 2.2: Condensation / 3.1: hydrolytic decarboxylation / 4.1: reductive cyclization;

DOI:10.1021/jm9904295

upstream raw materials:

(3'-methoxy-3-nitro-biphenyl-4-yl)-acetic acid

4-Bromo-1-fluoro-2-nitrobenzene

3-methoxyphenylboronic acid

4-fluoro-3'-methoxy-3-nitro-biphenyl