Synonyms:Ethyl (ethoxymethylene)cyanoacetate,98%
98% *data from raw suppliers
The study presents a Pd(II)-catalyzed cyclization method for the highly regio- and diastereoselective synthesis of optically active 4-vinyl-2-oxazolidinones from difunctional allylic N-tosylcarbamates, which serves as a convenient approach for the total synthesis of 1,4-dideoxy-1,4-imino-L-xylitol. Key chemicals used in the study include Pd(OAc)2 as the catalyst, LiBr or other halide ions as essential additives, and various homochiral alcohols as substrates. These reagents and substrates are crucial for the cyclization reaction, which involves aminopalladation of alkene and β-heteroatom elimination to regenerate Pd(II) species, yielding the desired 4-vinyl-2-oxazolidinones with high optical activity. The study also explores the mechanism of the reaction and demonstrates the utility of the method through the synthesis of 1,4-dideoxy-1,4-imino-L-xylitol, a potential glycosidase inhibitor.
The study presents a green and efficient one-pot method for synthesizing O-protected allylic alcohols through the organocatalytic oxidation of tertiary allylic amines, followed by a [2,3]-Meisenheimer rearrangement. The key chemicals used in the study include 2,2,2-trifluoroacetophenone as the organocatalyst, hydrogen peroxide (H2O2) as the oxidant, and a variety of solvents such as dichloromethane, THF, methanol, ethyl acetate, and tert-butanol, which were tested to optimize the reaction conditions. The purpose of these chemicals is to facilitate the conversion of allylic amine N-oxides to O-allylhydroxylamines in a sustainable manner, reducing waste generation and simplifying the purification process compared to traditional methods that use stoichiometric amounts of oxidants. The study also explored the substrate scope, demonstrating the method's tolerance for various substituents on the amine and allylic moiety, and leading to products in moderate to high yields.
The research discusses the asymmetric reduction of perfluoroalkyl ketones using chiral lithium alkoxides, with the aim of synthesizing chiral α-perfluoroalkyl alcohols in high enantiomeric excesses. The study focuses on the reaction of various perfluoroalkyl ketones with lithium (S)-1-phenylethoxide, yielding chiral alcohols with either (S) or (R) configuration, depending on the size of the perfluoroalkyl group. The researchers concluded that chiral lithium 1-phenylethoxide is effective in reducing aromatic perfluoroalkyl ketones with large perfluoroalkyl groups to (R)-perfluoroalkyl alcohols in good yields and high enantioselectivity, while trifluoromethyl ketones yield (S)-alcohols. This reduction method is particularly useful for perfluoroalkyl ketones that do not yield good results with the CBS reduction. The chemicals used in the process include 2,2,2-trifluoroacetophenone, perfluorooctan-1-one, and lithium (S)-1-phenylethoxide, among others.
What can I do for you?
Get Best Price
Total 8 Pictures about this product
