5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-N,N-dimethyl-thionicotinamide

Base Information

Chemical Name:5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-N,N-dimethyl-thionicotinamide
CAS No.:179072-26-5
Molecular Formula:C₂₇H₃₄N₂OS₂Si
Molecular Weight:494.797
Hs Code.:

Synonyms:5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-N,N-dimethyl-thionicotinamide

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Chemical Property of 5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-N,N-dimethyl-thionicotinamide

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Technology Process of 5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-N,N-dimethyl-thionicotinamide

There total 9 articles about 5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-N,N-dimethyl-thionicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 179072-24-3
5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-N,N-dimethyl-nicotinamide

: 179072-26-5
5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-N,N-dimethyl-thionicotinamide

Guidance literature:: With Lawessons reagent; In toluene; at 100 ℃; for 2h;
DOI:10.1080/07328319608007388

Reference yield:

: 37669-64-0
(5-bromopyridin-3-yl)methanol

: 179072-26-5
5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-N,N-dimethyl-thionicotinamide

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

2: 1.) BuLi / 1.) THF, -78 deg C, 5 min

3: 50 percent / tetrahydrofuran; diethyl ether

4: 90 percent / NH₄F / methanol / 3 h / 60 °C

5: 1.) HCl, 2.) SOCl₂ / 1.) CH₂Cl₂, 5 min, 2.) reflux, 2 h

6: 84 percent / Na / dimethylformamide / Ambient temperature

7: 70 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

8: methanol / Ambient temperature

9: 66 percent / Lawesson's reagent / toluene / 2 h / 100 °C

With Lawessons reagent; 1H-imidazole; hydrogenchloride; ammonium fluoride; n-butyllithium; thionyl chloride; sodium; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1080/07328319608007388

Reference yield:

: 129747-52-0
methyl 5-(hydroxymethyl)pyridine-3-carboxylate

: 179072-26-5
5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-N,N-dimethyl-thionicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) HCl, 2.) SOCl₂ / 1.) CH₂Cl₂, 5 min, 2.) reflux, 2 h

2: 84 percent / Na / dimethylformamide / Ambient temperature

3: 70 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

4: methanol / Ambient temperature

5: 66 percent / Lawesson's reagent / toluene / 2 h / 100 °C

With Lawessons reagent; 1H-imidazole; hydrogenchloride; thionyl chloride; sodium; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1080/07328319608007388