3-Acetyl-5-ethyl-2-hydroxy-cyanoformanilid

Base Information

• Chemical Name: 3-Acetyl-5-ethyl-2-hydroxy-cyanoformanilid
• CAS No.: 70978-26-6
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.239
• Mol file: 70978-26-6.mol

Synonyms:3-Acetyl-5-ethyl-2-hydroxy-cyanoformanilid

Chemical Property of 3-Acetyl-5-ethyl-2-hydroxy-cyanoformanilid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Acetyl-5-ethyl-2-hydroxy-cyanoformanilid

There total 3 articles about 3-Acetyl-5-ethyl-2-hydroxy-cyanoformanilid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-ethyl-2-hydroxy-3-nitroacetophenone (71002-71-6) → 3-Acetyl-5-ethyl-2-hydroxy-cyanoformanilid (70978-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / H₂ / 5percent Pd/C / ethanol

2: diethyl ether / 1 h / 0 °C

With hydrogen; palladium on activated charcoal; In diethyl ether; ethanol;

DOI:10.1021/jm00154a019

Reference yield:

3-ethyl-6-hydroxyacetophenone (24539-92-2) → 3-Acetyl-5-ethyl-2-hydroxy-cyanoformanilid (70978-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 44 percent / conc. HNO₃, conc. H₂SO₄ / -20 °C

2: 60 percent / H₂ / 5percent Pd/C / ethanol

3: diethyl ether / 1 h / 0 °C

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In diethyl ether; ethanol;

DOI:10.1021/jm00154a019

Reference yield:

carbonyl cyanide (1115-12-4) + 2-acetyl-6-amino-4-ethylphenol (70977-78-5) → 3-Acetyl-5-ethyl-2-hydroxy-cyanoformanilid (70978-26-6)

Guidance literature:

In diethyl ether; at 0 ℃; for 1h; Yield given;

DOI:10.1021/jm00154a019

upstream raw materials:

carbonyl cyanide

2-acetyl-6-amino-4-ethylphenol

3-ethyl-6-hydroxyacetophenone

5-ethyl-2-hydroxy-3-nitroacetophenone

Downstream raw materials:

N-(3-acetyl-5-ethyl-2-hydroxyphenyl)-1H-tetrazole-5-carboxamide