2-trifluoroacetamido-3-(2,5-difluorophenyl)-6-benzoylimidazo<1,2-a>pyridine

Base Information

Chemical Name:2-trifluoroacetamido-3-(2,5-difluorophenyl)-6-benzoylimidazo<1,2-a>pyridine
CAS No.:220259-91-6
Molecular Formula:C₂₂H₁₂F₅N₃O₂
Molecular Weight:445.348
Hs Code.:

Synonyms:2-trifluoroacetamido-3-(2,5-difluorophenyl)-6-benzoylimidazo<1,2-a>pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-trifluoroacetamido-3-(2,5-difluorophenyl)-6-benzoylimidazo<1,2-a>pyridine

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Technology Process of 2-trifluoroacetamido-3-(2,5-difluorophenyl)-6-benzoylimidazo<1,2-a>pyridine

There total 11 articles about 2-trifluoroacetamido-3-(2,5-difluorophenyl)-6-benzoylimidazo<1,2-a>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 407-25-0
trifluoroacetic anhydride

: 220259-85-8
1,2-dihydro-2-p-toluenesulfonimido-5-benzoyl-N-<1-(2,5-difluorophenyl)carbamoylmethyl>pyridine

: 220259-91-6
2-trifluoroacetamido-3-(2,5-difluorophenyl)-6-benzoylimidazo<1,2-a>pyridine

Guidance literature:: In dichloromethane; at 30 ℃; for 2.5h;
DOI:10.1021/jm9810405

Reference yield:

: 58757-38-3
6-Chloronicotinoyl chloride

: 220259-91-6
2-trifluoroacetamido-3-(2,5-difluorophenyl)-6-benzoylimidazo<1,2-a>pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / AlCl₃ / Heating

2: 85 percent / NH₃ / ethanol / 16 h / 145 °C

3: 91 percent / pyridine / 80 - 90 °C

4: 95 percent / DIPEA / dimethylformamide / 24 h

5: 95 percent / CH₂Cl₂ / 2.5 h / 30 °C

With pyridine; aluminium trichloride; ammonia; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9810405

Reference yield:

: 53439-80-8
2-amino-5-benzoylpyridine

: 220259-91-6
2-trifluoroacetamido-3-(2,5-difluorophenyl)-6-benzoylimidazo<1,2-a>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / pyridine / 80 - 90 °C

2: 95 percent / DIPEA / dimethylformamide / 24 h

3: 95 percent / CH₂Cl₂ / 2.5 h / 30 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9810405