(E)-1,1,1-trifluoro-N-(2-(3-(4-nitrophenyl)acryloyl)phenyl)methanesulfonamide

Base Information

Chemical Name:(E)-1,1,1-trifluoro-N-(2-(3-(4-nitrophenyl)acryloyl)phenyl)methanesulfonamide
CAS No.:1399086-38-4
Molecular Formula:C₁₆H₁₁F₃N₂O₅S
Molecular Weight:400.335
Hs Code.:

Synonyms:(E)-1,1,1-trifluoro-N-(2-(3-(4-nitrophenyl)acryloyl)phenyl)methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1,1,1-trifluoro-N-(2-(3-(4-nitrophenyl)acryloyl)phenyl)methanesulfonamide

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Technology Process of (E)-1,1,1-trifluoro-N-(2-(3-(4-nitrophenyl)acryloyl)phenyl)methanesulfonamide

There total 2 articles about (E)-1,1,1-trifluoro-N-(2-(3-(4-nitrophenyl)acryloyl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 123134-62-3,130820-61-0
(E)-1-(2'-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one

: 1399086-38-4
(E)-1,1,1-trifluoro-N-(2-(3-(4-nitrophenyl)acryloyl)phenyl)methanesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at -78 - 20 ℃; for 4h;
DOI:10.1002/anie.201202161

Reference yield:

: 551-93-9
2-aminoacetophenone

: 1399086-38-4
(E)-1,1,1-trifluoro-N-(2-(3-(4-nitrophenyl)acryloyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 24 h / 20 °C / Cooling with ice

2: triethylamine / dichloromethane / 4 h / -78 - 20 °C

With triethylamine; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1002/anie.201202161

Reference yield: 96.0%

: 1399086-38-4
(E)-1,1,1-trifluoro-N-(2-(3-(4-nitrophenyl)acryloyl)phenyl)methanesulfonamide

: 76457-91-5
3-(4-bromophenyl)prop-2-ynal

: 1399086-26-0
(R)-(E)-2-(4-bromophenyl)-4-hydroxy-4-(4-nitrostyryl)-1-(trifluoromethylsulfonyl)-1,4-dihydroquinoline-3-carbaldehyde

Guidance literature:: With (R,R)-2,5-diphenylpyrrolidine; In toluene; at 0 ℃; for 5h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/anie.201202161