4-BROMO-7-METHYLTRYPTOPHOL

Base Information

• Chemical Name: 4-BROMO-7-METHYLTRYPTOPHOL
• CAS No.: 214915-69-2
• Molecular Formula: C₁₁H₁₂BrNO
• Molecular Weight: 254.126
• Hs Code.: 2933990090
• Mol file: 214915-69-2.mol

Synonyms:4-BROMO-7-METHYLTRYPTOPHOL

Chemical Property of 4-BROMO-7-METHYLTRYPTOPHOL

Chemical Property:

• Vapor Pressure: 1.07E-07mmHg at 25°C
• Refractive Index: 1.678
• Boiling Point: 417°C at 760 mmHg
• PKA: 14.83±0.10(Predicted)
• Flash Point: 206°C
• PSA: 62.04000
• Density: 1.543g/cm³
• LogP: 2.80120
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Bromo-7-methyl-1H-indol-3-yl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-7-METHYLTRYPTOPHOL

There total 4 articles about 4-BROMO-7-METHYLTRYPTOPHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + 5-bromo-2-methyl-phenylhydrazine hydrochloride → 4-bromo-7-methyltryptophol (214915-69-2)

Guidance literature:

2,3-dihydro-2H-furan; 5-bromo-2-methyl-phenylhydrazine hydrochloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 14h;

With zinc(II) chloride; In ethylene glycol; at 170 ℃; for 4h;

Reference yield: 25.0%

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + (5-bromo-2-methylphenyl)hydrazine (752200-75-2) → 4-bromo-7-methyltryptophol (214915-69-2)

Guidance literature:

2,3-dihydro-2H-furan; (5-bromo-2-methylphenyl)hydrazine; In tetrahydrofuran; water; at 0 - 20 ℃; for 14h;

zinc(II) chloride; In ethylene glycol; at 170 ℃; for 4h;

Reference yield:

t-butyl 4-bromo-2,3-dihydro-3-hydroxy-7-methyl-2-oxo-1H-indolyl-3-acetate → 4-bromo-7-methyltryptophol (214915-69-2)

Guidance literature:

t-butyl 4-bromo-2,3-dihydro-3-hydroxy-7-methyl-2-oxo-1H-indolyl-3-acetate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 10 ℃; for 4.5 - 5.5h; Heating / reflux;

With hydrogenchloride; In water; ethyl acetate; at 0 - 10 ℃; pH=2 - 3;

upstream raw materials:

4-[(5-bromo-2-methyl-phenyl)-hydrazono]-butan-1-ol

2,3-dihydro-2H-furan

(5-bromo-2-methylphenyl)hydrazine