(-)-ethyl (R)-2-(1-(4-(tert-butoxycarbonyl)phenyl)-2-methyl-1H-indol-3-yl)-5-methylhexanoate

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Chemical Name:(-)-ethyl (R)-2-(1-(4-(tert-butoxycarbonyl)phenyl)-2-methyl-1H-indol-3-yl)-5-methylhexanoate
CAS No.:1264995-32-5
Molecular Formula:C₂₉H₃₈N₂O₄
Molecular Weight:478.632
Hs Code.:

Synonyms:(-)-ethyl (R)-2-(1-(4-(tert-butoxycarbonyl)phenyl)-2-methyl-1H-indol-3-yl)-5-methylhexanoate

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Chemical Property of (-)-ethyl (R)-2-(1-(4-(tert-butoxycarbonyl)phenyl)-2-methyl-1H-indol-3-yl)-5-methylhexanoate

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Technology Process of (-)-ethyl (R)-2-(1-(4-(tert-butoxycarbonyl)phenyl)-2-methyl-1H-indol-3-yl)-5-methylhexanoate

There total 2 articles about (-)-ethyl (R)-2-(1-(4-(tert-butoxycarbonyl)phenyl)-2-methyl-1H-indol-3-yl)-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: ethyl 2-diazo-5-methylhexanoate

: 1264995-59-6
tert-butyl 4-(2-methyl-1H-indol-1-yl)phenylcarbamate

: 1264995-32-5
(-)-ethyl (R)-2-(1-(4-(tert-butoxycarbonyl)phenyl)-2-methyl-1H-indol-3-yl)-5-methylhexanoate

Guidance literature:: With tetrakis[μ-(αS)-α-(1,1-dimethylethyl)-2,3-dihydro-1H-naphtho[1,8-cd]pyridine-2-acetato-κO:.kappaO']dirhodium(II)(Rh-Rh); In toluene; at -78 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja1093309

Reference yield:

: 95-20-5
2-methyl-1H-indole

: 159217-89-7
N-Boc-4-iodoaniline

: 1264995-32-5
(-)-ethyl (R)-2-(1-(4-(tert-butoxycarbonyl)phenyl)-2-methyl-1H-indol-3-yl)-5-methylhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium phosphate / toluene / 48 h / 110 °C / Inert atmosphere; Sealed tube

2: tetrakis[μ-(αS)-α-(1,1-dimethylethyl)-2,3-dihydro-1H-naphtho[1,8-cd]pyridine-2-acetato-κO:.kappaO']dirhodium(II)(Rh-Rh) / toluene / -78 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; tetrakis[μ-(αS)-α-(1,1-dimethylethyl)-2,3-dihydro-1H-naphtho[1,8-cd]pyridine-2-acetato-κO:.kappaO']dirhodium(II)(Rh-Rh); In toluene;
DOI:10.1021/ja1093309