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Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL N-(4-IODOPHENYL)CARBAMATE is used as a reagent in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and enhance the biological activity of existing ones. Its role in modifying biological activity makes it a valuable tool in the creation of compounds with improved therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, TERT-BUTYL N-(4-IODOPHENYL)CARBAMATE is utilized as a reagent in the synthesis of agrochemicals, aiding in the production of substances that can protect crops and enhance agricultural productivity.
Used in Research and Development:
TERT-BUTYL N-(4-IODOPHENYL)CARBAMATE is used as a precursor in the synthesis of biologically active molecules and pharmacologically important compounds, playing a crucial role in advancing scientific research and the discovery of novel therapeutic agents.
Given the potential impact of TERT-BUTYL N-(4-IODOPHENYL)CARBAMATE on human health and the environment, it is imperative to handle and utilize TERT-BUTYL N-(4-IODOPHENYL)CARBAMATE with caution, adhering to the necessary safety measures and guidelines.

InChI:InChI=1/C11H14INO2/c1-11(2,3)15-10(14)13-9-6-4-8(12)5-7-9/h4-7H,1-3H3,(H,13,14)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 540-37-4 p-aminoiodobenzene 
• 34619-03-9 tert-butyldicarbonate 
• 3422-01-3 tert-butyl phenylcarbamate 
• 1093102-82-9 4-((tert-butoxycarbonyl)amino)phenyl trifluoromethanesulfonate 
• 71026-66-9 N-(tert-butoxycarbonyl)-1,4-phenylenediamine 
• 106-50-3 1,4-phenylenediamine 
• 74367-81-0 4-iodoaniline hydrochloride 

Downstream Products

• 241499-50-3 [4-(3,3-dimethyl-but-1-ynyl)-phenyl]-carbamic acid tert-butyl ester 
• 628293-21-0 (R)-N-4-iodophenyl-N'-(1-ethyl-2-hydroxy)ethylurea 
• 628293-29-8 (S)-N-4-iodophenyl-N'-(1-ethyl-2-hydroxy)ethylurea 
• 317842-68-5 N-tert-butoxycarbonyl-4-(trimethylsilylethynyl)aniline 
• 224635-57-8 ⁽³⁾-[4-(tert-Butoxycarbonylamino)phenyl]-propenoic acid methyl ester 
• 945413-50-3 1-oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-(4-(tert-butyloxycarbonyl)aminophenyl)hept-6-yne 
• 241499-52-5 4-(3,3-dimethyl-butyl)-phenylamine 
• 241499-51-4 [4-(3,3-dimethyl-butyl)-phenyl]-carbamic acid tert-butyl ester 
• 241499-55-8 [4-(3,3-dimethyl-butyl)-phenyl]-(3-methyl-but-2-enyl)-piperidin-4-yl-amine 
• 241499-53-6 4-[4-(3,3-Dimethyl-butyl)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester 
• 241499-54-7 4-[[4-(3,3-Dimethyl-butyl)-phenyl]-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester 
• 241499-17-2 [1-(4-Dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethyl-butyl)-phenyl]-(3-methyl-but-2-enyl)-amine 
• 239088-84-7 2-<(4'-Boc-amino)phenyl>benzofuran 
• 329020-64-6 (4-trimethylstannanylphenyl)carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Efficient and eco-friendly synthesis of iodinated aromatic building blocks promoted by iodine and hydrogen peroxide in water: A mechanistic investigation by mass spectrometry

The reaction of aromatic and heteroaromatic compounds with molecular iodine in the presence of aqueous hydrogen peroxide using water without any co-solvent at 50 °C for 24 h produced versatile iodinated organic molecules with potential application in organic synthesis and medicine in very good yields. In addition, a mechanistic investigation for the iodination process was carried out by mass spectrometry.

Complexes featuring N-heterocyclic carbenes with bowl-shaped wingtips

Three imidazolium salts having their two N-substituents equipped with remote calix[4]arenyl termini have been synthesised and converted into N-heterocyclic carbene (NHC) complexes of the type [PdCl2(NHC)(pyridine)]. An X-ray diffraction study c

NAMPT MODULATORS

Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.

Base-Mediated Generation of Ketenimines from Ynamides: [3+2] Annulation with Azaallyl Anions

Under basic conditions and heat, ynamides can serve as precursors to ketenimines, whose synthetic potential is often hampered by their difficulty of access. Herein, we report that they can undergo a [3+2] cycloaddition with 2-azaallyl anions, obtained from benzylimines under the same reaction conditions. This reaction between two highly reactive intermediates, both generated in situ from bench stable starting materials, gives access to various nitrogen-rich heterocycles. The reaction usually proceeds with excellent diastereoselectivity, in favor of the cis adduct. Deuteration experiments and DFT calculations helped rationalize the regio- and stereoselectivity of the process as well as the formation of side products. (Figure presented.).

Mild deprotection of the: N-tert -butyloxycarbonyl (N -Boc) group using oxalyl chloride

We report a mild method for the selective deprotection of the N-Boc group from a structurally diverse set of compounds, encompassing aliphatic, aromatic, and heterocyclic substrates by using oxalyl chloride in methanol. The reactions take place under room temperature conditions for 1-4 h with yields up to 90percent. This mild procedure was applied to a hybrid, medicinally active compound FC1, which is a novel dual inhibitor of IDO1 and DNA Pol gamma. A broader mechanism involving the electrophilic character of oxalyl chloride is postulated for this deprotection strategy. This journal is

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

Janus kinases (JAKs) are non-receptor tyrosine kinases that are essential components of the JAK-STAT signaling pathway. Associated aberrant signaling is responsible for many forms of cancer and disorders of the immune system. The present focus is on the d

A para-C–H Functionalization of Aniline Derivatives via In situ Generated Bulky Hypervalent Iodinium Reagents

A practical para-C-H functionalization of aniline derivatives has been developed using an in situ generated bulky hypervalent iodinium reagent. Para-iodo, bromo, chloro, nitro, trifluormethyl aniline derivatives can be obtained efficiently, in many cases in 10 min in a transition metal-free manner. Medicinal chemicals or intermediates can be purified without column chromatography or recrystallization, which significantly reduces the waste and simplifies the work-up process.

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

Multicomponent Oxidative Trifluoromethylation of Alkynes with Photoredox Catalysis: Synthesis of α-Trifluoromethyl Ketones

The direct oxidative addition of CF3 and H2O to alkynes was achieved with photoredox catalysis to obtain α-trifluoromethyl ketones via rapid enol-keto tautomerization. The reaction exhibits high functional group tolerance and regioselectivity. Heterocycles of various sizes containing CF3 were synthesized from the α-CF3-substituted diketones obtained through the protocol, thereby demonstrating the versatile applicability of the method. Mechanistic studies of the reaction with isotopes provided insight into the reaction pathway.

Simple and Efficient Generation of Aryl Radicals from Aryl Triflates: Synthesis of Aryl Boronates and Aryl Iodides at Room Temperature

Despite the wide use of aryl radicals in organic synthesis, current methods to prepare them from aryl halides, carboxylic acids, boronic acids, and diazonium salts suffer from limitations. Aryl triflates, easily obtained from phenols, are promising aryl radical progenitors but remain elusive in this regard. Inspired by the single electron transfer process for aryl halides to access aryl radicals, we developed a simple and efficient protocol to convert aryl triflates to aryl radicals. Our success lies in exploiting sodium iodide as the soft electron donor assisted by light. This strategy enables the scalable synthesis of two types of important organic molecules, i.e., aryl boronates and aryl iodides, in good to high yields, with broad functional group compatibility in a transition-metal-free manner at room temperature. This protocol is anticipated to find potential applications in other aryl-radical-involved reactions by using aryl triflates as aryl radical precursors.