2-(S)-amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid

Base Information

• Chemical Name: 2-(S)-amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid
• CAS No.: 1455087-02-1
• Molecular Formula: C₁₉H₁₇N₃O₅
• Molecular Weight: 367.361
• Mol file: 1455087-02-1.mol

Synonyms:2-(S)-amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid

Chemical Property of 2-(S)-amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(S)-amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid

There total 7 articles about 2-(S)-amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(S)-tert-butoxycarbonylamino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid (1455091-19-6) → 2-(S)-amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid (1455087-02-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

2-(chloromethyl)-4-phenoxybenzoic acid methyl ester (1455091-04-9) → 2-(S)-amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid (1455087-02-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

2: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

3: sodium methylate / methanol / 30 h / Reflux

4: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With sodium methylate; potassium carbonate; trifluoroacetic acid; sodium iodide; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester (1455091-06-1) → 2-(S)-amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propionic acid (1455087-02-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

2: sodium methylate / methanol / 30 h / Reflux

3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With sodium methylate; trifluoroacetic acid; In methanol; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

5-bromophthalide