(2S)-Methyl 2-((Z)-3-iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carboxylate

Base Information

Chemical Name:(2S)-Methyl 2-((Z)-3-iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carboxylate
CAS No.:160360-11-2
Molecular Formula:C₁₉H₂₆INO₄
Molecular Weight:459.324
Hs Code.:

Synonyms:(2S)-Methyl 2-((Z)-3-iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carboxylate

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Chemical Property of (2S)-Methyl 2-((Z)-3-iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carboxylate

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Technology Process of (2S)-Methyl 2-((Z)-3-iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carboxylate

There total 7 articles about (2S)-Methyl 2-((Z)-3-iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026124-76-4
(S)-2-((Z)-3-Iodo-allyl)-pyrrolidine-2-carboxylic acid

: 160360-11-2
(2S)-Methyl 2-((Z)-3-iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / dioxane / 24 h / Ambient temperature

2: methanol; diethyl ether

3: CF₃CO₂H / CH₂Cl₂ / 2 h / Ambient temperature

4: i-Pr₂NEt / acetonitrile / 12 h / Heating

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jo00106a023

Reference yield:

: 160360-13-4
(Z)-(2S,5S)-5-(3-Iodo-2-propenyl)-2-tert-butyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one

: 160360-11-2
(2S)-Methyl 2-((Z)-3-iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 10percent aq. H₂SO₄ / 24 h / Ambient temperature

2: aq. NaOH / dioxane / 24 h / Ambient temperature

3: methanol; diethyl ether

4: CF₃CO₂H / CH₂Cl₂ / 2 h / Ambient temperature

5: i-Pr₂NEt / acetonitrile / 12 h / Heating

With sodium hydroxide; sulfuric acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jo00106a023

Reference yield:

: 160360-12-3
(E)-(2S,5S)-5-(3-(Trimethylsilyl)-2-propenyl)-2-tert-butyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one

: 160360-11-2
(2S)-Methyl 2-((Z)-3-iodo-2-propenyl)-1-<2-(3,4-dimethoxyphenyl)ethyl>pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) ICl, CF₃CO₂H, 2.) KF*2H₂O / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) DMSO, r.t., 19 h

2: 10percent aq. H₂SO₄ / 24 h / Ambient temperature

3: aq. NaOH / dioxane / 24 h / Ambient temperature

4: methanol; diethyl ether

5: CF₃CO₂H / CH₂Cl₂ / 2 h / Ambient temperature

6: i-Pr₂NEt / acetonitrile / 12 h / Heating

With potassium fluoride; sodium hydroxide; sulfuric acid; Iodine monochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jo00106a023