7-bromo-1-(4-fluorophenyl)-1,4-dihydro-2-hydroxy-4-oxo-3-quinolinecarboxamide

Base Information

Chemical Name:7-bromo-1-(4-fluorophenyl)-1,4-dihydro-2-hydroxy-4-oxo-3-quinolinecarboxamide
CAS No.:131994-61-1
Molecular Formula:C₁₆H₁₀BrFN₂O₃
Molecular Weight:377.169
Hs Code.:

Synonyms:7-bromo-1-(4-fluorophenyl)-1,4-dihydro-2-hydroxy-4-oxo-3-quinolinecarboxamide

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Chemical Property of 7-bromo-1-(4-fluorophenyl)-1,4-dihydro-2-hydroxy-4-oxo-3-quinolinecarboxamide

Chemical Property:

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Technology Process of 7-bromo-1-(4-fluorophenyl)-1,4-dihydro-2-hydroxy-4-oxo-3-quinolinecarboxamide

There total 4 articles about 7-bromo-1-(4-fluorophenyl)-1,4-dihydro-2-hydroxy-4-oxo-3-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 131994-69-9
ethyl 7-bromo-1-(4-fluorophenyl)-1,4-dihydro-2-hydroxy-4-oxo-3-quinolinecarboxylate

: 131994-61-1
7-bromo-1-(4-fluorophenyl)-1,4-dihydro-2-hydroxy-4-oxo-3-quinolinecarboxamide

Guidance literature:: With ammonia; at 125 ℃; for 14h;
DOI:10.1021/jm00063a008

Reference yield:

: 131994-59-7
ethyl 3,3-di(methylthio)-2-(4-bromo-2-chlorobenzoyl)propenoate

: 131994-61-1
7-bromo-1-(4-fluorophenyl)-1,4-dihydro-2-hydroxy-4-oxo-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / Heating

2: 71 percent / 1N aq. KOH / Heating

3: 67 percent / ethanolic NH₃ / 14 h / 125 °C

With potassium hydroxide; ammonia; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00063a008

Reference yield:

: 371-40-4
4-fluoroaniline

: 131994-61-1
7-bromo-1-(4-fluorophenyl)-1,4-dihydro-2-hydroxy-4-oxo-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / Heating

2: 71 percent / 1N aq. KOH / Heating

3: 67 percent / ethanolic NH₃ / 14 h / 125 °C

With potassium hydroxide; ammonia; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00063a008