C₆₃H₈₂N₄O₁₄Si

Base Information

• Chemical Name: C₆₃H₈₂N₄O₁₄Si
• CAS No.: 262279-38-9
• Molecular Formula: C₆₃H₈₂N₄O₁₄Si
• Molecular Weight: 1147.45
• Mol file: 262279-38-9.mol

Synonyms:C₆₃H₈₂N₄O₁₄Si

Chemical Property of C₆₃H₈₂N₄O₁₄Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₃H₈₂N₄O₁₄Si

There total 37 articles about C₆₃H₈₂N₄O₁₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R,4R,5R)-(E)-4-(para-methoxybenzyloxy)-3,5-dimethyl-6-oxo-1-ol 2,2-dimethyl-1,3-propane acetal (313696-74-1) → C63H82N4O14Si (262279-38-9)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 88 percent / NiCl₂; CrCl₂ / tetrahydrofuran; dimethylsulfoxide / 20 °C

2.1: NaNO₂; H₂ / PtO₂ / ethyl acetate; ethanol / 3 h / 3040.2 Torr

3.1: DIBAL-H / CH₂Cl₂; hexane / 2 h / -78 °C

4.1: 411 mg / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 1.5 h / 20 °C

5.1: 87 percent / aq. DDQ / CH₂Cl₂ / 0.75 h / 20 °C

6.1: 82 percent / DMAP / CH₂Cl₂ / 0.5 h / 0 °C

7.1: triethylphosphine / dimethylformamide / 0.5 h / 20 °C

7.2: 86 percent / DBU / dimethylformamide; tetrahydrofuran / 0.5 h / 0 °C

8.1: 65 percent / PPTS / ethanol / 22 h / 50 °C

9.1: 2,4,6-trichlorobenzoyl chloride; diisopropylethyl amine / benzene / 10 h / 20 °C

9.2: 66 percent / DMAP / benzene

10.1: PPTS / acetone; H₂O / 120 h / Heating

11.1: 10.7 mg / PPTS; 4 Angstroem molecular sieves / benzene / Heating

With pyridine; chromium dichloride; dmap; 4 A molecular sieve; 2,4,6-trichlorobenzoyl chloride; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; sodium nitrite; triethylphosphine; platinum(IV) oxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone; benzene; 7.1: Schlosser-Wittig olefination / 9.1: Yonemitsu/Yamaguchi reaction;

DOI:10.1021/ja002377a

Reference yield:

2,2-Dimethyl-propionic acid (3S,4R,5S)-5-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-4-methyl-7-oxo-heptyl ester → C63H82N4O14Si (262279-38-9)

Guidance literature:

Multi-step reaction with 15 steps

1.1: 88 percent / TiCl₄ / CH₂Cl₂ / 8 h / -78 °C

2.1: 87 percent / Proton Sponge(R) / CH₂Cl₂ / 15 h / 0 - 25 °C

3.1: O₃; pyridine / methanol / 0.17 h / -78 °C

3.2: methylsulfide / methanol / 10 h / 25 °C

4.1: 1.18 g / CrCl₂ / tetrahydrofuran / 20 °C

5.1: 88 percent / NiCl₂; CrCl₂ / tetrahydrofuran; dimethylsulfoxide / 20 °C

6.1: NaNO₂; H₂ / PtO₂ / ethyl acetate; ethanol / 3 h / 3040.2 Torr

7.1: DIBAL-H / CH₂Cl₂; hexane / 2 h / -78 °C

8.1: 411 mg / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 1.5 h / 20 °C

9.1: 87 percent / aq. DDQ / CH₂Cl₂ / 0.75 h / 20 °C

10.1: 82 percent / DMAP / CH₂Cl₂ / 0.5 h / 0 °C

11.1: triethylphosphine / dimethylformamide / 0.5 h / 20 °C

11.2: 86 percent / DBU / dimethylformamide; tetrahydrofuran / 0.5 h / 0 °C

12.1: 65 percent / PPTS / ethanol / 22 h / 50 °C

13.1: 2,4,6-trichlorobenzoyl chloride; diisopropylethyl amine / benzene / 10 h / 20 °C

13.2: 66 percent / DMAP / benzene

14.1: PPTS / acetone; H₂O / 120 h / Heating

15.1: 10.7 mg / PPTS; 4 Angstroem molecular sieves / benzene / Heating

With pyridine; chromium dichloride; dmap; 4 A molecular sieve; 2,4,6-trichlorobenzoyl chloride; hydrogen; pyridinium p-toluenesulfonate; titanium tetrachloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; diisobutylaluminium hydride; Dess-Martin periodane; ozone; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; sodium nitrite; triethylphosphine; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone; benzene; 4.1: Takai olefination / 11.1: Schlosser-Wittig olefination / 13.1: Yonemitsu/Yamaguchi reaction;

DOI:10.1021/ja002377a

Reference yield:

2,2-Dimethyl-propionic acid (3S,4R,5S,7S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-3,7-dimethoxy-4,8-dimethyl-9-oxo-nonyl ester → C63H82N4O14Si (262279-38-9)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 1.18 g / CrCl₂ / tetrahydrofuran / 20 °C

2.1: 88 percent / NiCl₂; CrCl₂ / tetrahydrofuran; dimethylsulfoxide / 20 °C

3.1: NaNO₂; H₂ / PtO₂ / ethyl acetate; ethanol / 3 h / 3040.2 Torr

4.1: DIBAL-H / CH₂Cl₂; hexane / 2 h / -78 °C

5.1: 411 mg / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 1.5 h / 20 °C

6.1: 87 percent / aq. DDQ / CH₂Cl₂ / 0.75 h / 20 °C

7.1: 82 percent / DMAP / CH₂Cl₂ / 0.5 h / 0 °C

8.1: triethylphosphine / dimethylformamide / 0.5 h / 20 °C

8.2: 86 percent / DBU / dimethylformamide; tetrahydrofuran / 0.5 h / 0 °C

9.1: 65 percent / PPTS / ethanol / 22 h / 50 °C

10.1: 2,4,6-trichlorobenzoyl chloride; diisopropylethyl amine / benzene / 10 h / 20 °C

10.2: 66 percent / DMAP / benzene

11.1: PPTS / acetone; H₂O / 120 h / Heating

12.1: 10.7 mg / PPTS; 4 Angstroem molecular sieves / benzene / Heating

With pyridine; chromium dichloride; dmap; 4 A molecular sieve; 2,4,6-trichlorobenzoyl chloride; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; nickel dichloride; sodium nitrite; triethylphosphine; platinum(IV) oxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone; benzene; 1.1: Takai olefination / 8.1: Schlosser-Wittig olefination / 10.1: Yonemitsu/Yamaguchi reaction;

DOI:10.1021/ja002377a

upstream raw materials:

N-Methylformamide

2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazole-4-carbaldehyde

(5S,6S)-(E)-methyl 6-methoxy-5-methyl-6-(2-tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-hex-3-enoate

(S)-(E)-tert-butyl 3-(tert-butyldiphenylsilyl)oxy-6-iodo-hex-5-enoate