pentafluorophenyl 2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carboxylic ester

Base Information

• Chemical Name: pentafluorophenyl 2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carboxylic ester
• CAS No.: 905845-32-1
• Molecular Formula: C₂₄H₁₈F₅NO₅
• Molecular Weight: 495.403
• Mol file: 905845-32-1.mol

Synonyms:pentafluorophenyl 2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carboxylic ester

Chemical Property of pentafluorophenyl 2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carboxylic ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pentafluorophenyl 2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carboxylic ester

There total 3 articles about pentafluorophenyl 2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carboxylic ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bis-pentafluorophenyl 2-butyl-cycloprop-2-ene-1,1-bis-carboxylic ester (905845-18-3) + lithium (S)-2-oxo-4-phenyloxazolidin-3-ide → pentafluorophenyl 2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carboxylic ester (905845-32-1) + pentafluorophenyl 2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carboxylic ester

Guidance literature:

In tetrahydrofuran; dichloromethane; pentane; at -78 - 20 ℃;

DOI:10.1021/ol060847l

Reference yield:

2-butyl-cycloprop-2-ene-1,1-dicarboxylic acid (905845-02-5) → pentafluorophenyl 2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carboxylic ester (905845-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / ethyldiisopropylamine / CH₂Cl₂ / 0.5 h / cooling

2: 90 percent / tetrahydrofuran; pentane; CH₂Cl₂ / -78 - 20 °C

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; pentane;

DOI:10.1021/ol060847l

Reference yield:

dimethyl ester of 1-butylcyclopropene-3,3-dicarboxylic acid (34721-76-1) → pentafluorophenyl 2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carboxylic ester (905845-32-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / KOH / methanol; H₂O / 14 h / 20 °C

2: 82 percent / ethyldiisopropylamine / CH₂Cl₂ / 0.5 h / cooling

3: 90 percent / tetrahydrofuran; pentane; CH₂Cl₂ / -78 - 20 °C

With potassium hydroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; pentane;

DOI:10.1021/ol060847l

upstream raw materials:

bis-pentafluorophenyl 2-butyl-cycloprop-2-ene-1,1-bis-carboxylic ester

2-butyl-cycloprop-2-ene-1,1-dicarboxylic acid

dimethyl ester of 1-butylcyclopropene-3,3-dicarboxylic acid

Downstream raw materials:

2-butyl-1-(2-oxo-4S-phenyl-oxazolidine-3-carbonyl)-cycloprop-2-ene carbonyl azide