[(7-benzyl-4-hydroxy-1-methyl-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-acetic acid

Base Information

Chemical Name:[(7-benzyl-4-hydroxy-1-methyl-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-acetic acid
CAS No.:1392841-70-1
Molecular Formula:C₁₉H₁₇N₃O₅
Molecular Weight:367.361
Hs Code.:

Synonyms:[(7-benzyl-4-hydroxy-1-methyl-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-acetic acid

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Chemical Property of [(7-benzyl-4-hydroxy-1-methyl-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-acetic acid

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Technology Process of [(7-benzyl-4-hydroxy-1-methyl-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-acetic acid

There total 9 articles about [(7-benzyl-4-hydroxy-1-methyl-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392839-25-6
7-benzyl-4-hydroxy-1-methyl-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

: 56-40-6,18875-39-3,25718-94-9
glycine

: 1392841-70-1
[(7-benzyl-4-hydroxy-1-methyl-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-acetic acid

Guidance literature:: With sodium methylate; In methanol; for 16h; Reflux;

Reference yield:

: 174740-67-1
dimethyl <2-(ethoxycarbonyl)ethylidene>malonate

: 1392841-70-1
[(7-benzyl-4-hydroxy-1-methyl-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: N,N-dimethyl-formamide / 3 h / 80 °C

2.1: ethanol / 5 h / Reflux

3.1: pyridine; lithium iodide / 1 h / Reflux

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

4.2: 16 h / 20 °C

4.3: 16 h / 20 °C

5.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: sodium methylate / methanol

6.2: pH 4

7.1: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

8.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

9.1: sodium methylate / methanol / 16 h / Reflux

With pyridine; oxalyl dichloride; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; bis-triphenylphosphine-palladium(II) chloride; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 33707-28-7
1-benzyl-2-oxo-1,2-dihydro-pyridine-3,4-dicarboxylic acid 4-ethyl ester

: 1392841-70-1
[(7-benzyl-4-hydroxy-1-methyl-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

1.2: 16 h / 20 °C

1.3: 16 h / 20 °C

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium methylate / methanol

3.2: pH 4

4.1: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

5.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

6.1: sodium methylate / methanol / 16 h / Reflux

With oxalyl dichloride; sodium methylate; potassium carbonate; sodium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; bis-triphenylphosphine-palladium(II) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide;