2-(4-cyanophenyl)-N-(6-methoxy-4-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-2-yl)acetamide

Base Information

Chemical Name:2-(4-cyanophenyl)-N-(6-methoxy-4-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-2-yl)acetamide
CAS No.:1596336-55-8
Molecular Formula:C₂₅H₂₂N₆O₃
Molecular Weight:454.488
Hs Code.:

Synonyms:2-(4-cyanophenyl)-N-(6-methoxy-4-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-2-yl)acetamide

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Chemical Property of 2-(4-cyanophenyl)-N-(6-methoxy-4-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-2-yl)acetamide

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Technology Process of 2-(4-cyanophenyl)-N-(6-methoxy-4-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-2-yl)acetamide

There total 4 articles about 2-(4-cyanophenyl)-N-(6-methoxy-4-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1596337-09-5
(2-chloro-6-methoxypyridin-4-yl)-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

: 117753-06-7
2-(4-cyanophenyl)acetamide

: 1596336-55-8
2-(4-cyanophenyl)-N-(6-methoxy-4-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-2-yl)acetamide

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 120 ℃; for 18h; Inert atmosphere;

Reference yield:

: 175791-53-4
5-Iodopyrrolo<2,3-d>pyrimidine

: 1596336-55-8
2-(4-cyanophenyl)-N-(6-methoxy-4-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C

2.2: 16 h / 0 - 20 °C

3.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl-formamide / 18 h / 120 °C / Inert atmosphere

With isopropylmagnesium chloride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 15855-06-8
2-chloro-6-methoxy-isonicotinic acid

: 1596336-55-8
2-(4-cyanophenyl)-N-(6-methoxy-4-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 18 h / 20 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C

2.2: 16 h / 0 - 20 °C

3.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl-formamide / 18 h / 120 °C / Inert atmosphere

With isopropylmagnesium chloride; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;